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Lifestyle Interventions for Breast Cancer Prevention

  • Risk and Prevention (ME Wood, Section Editor)
  • Published:
Current Breast Cancer Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

One in eight women in the USA will develop breast cancer in her lifetime. Despite established efficacy, the use of pharmacotherapy for breast cancer prevention is limited by concerns over toxicities that may negatively influence quality of life. Additional interventions for breast cancer prevention are needed.

Recent Findings

There is emerging evidence from observational studies that obesity, physical inactivity, sedentary behavior, and dietary patterns are associated with breast cancer risk. Randomized trials are necessary to provide unbiased efficacy estimates of lifestyle changes on breast cancer risk, but such trials require a large sample size, long-term follow-up, and substantial financial investment. One approach to manage these barriers is to leverage recent advances in precision prevention to identify high-risk study participants to reduce sample size or shorten length of follow-up.

Summary

Precision prevention approaches may accelerate the translation of epidemiologic discoveries into proven population-based breast cancer prevention interventions.

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Funding

Research reported in this publication was supported by the National Cancer Institute (K99-CA218603; R25-CA203650).

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Authors and Affiliations

  1. Dana-Farber Cancer Institute, 450 Brookline Ave., Boston, MA, USA

    Justin C. Brown & Jennifer A. Ligibel

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  1. Justin C. Brown
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  2. Jennifer A. Ligibel
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Corresponding author

Correspondence to Jennifer A. Ligibel.

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The authors declare that they have no competing interests.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Risk and Prevention

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Brown, J.C., Ligibel, J.A. Lifestyle Interventions for Breast Cancer Prevention. Curr Breast Cancer Rep 10, 202–208 (2018). https://doi.org/10.1007/s12609-018-0281-z

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  • DOI: https://doi.org/10.1007/s12609-018-0281-z

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