Selenium Concentrations and Mortality Among Community-Dwelling Older Adults: Results from ilSIRENTE Study
Selenium has a wide range of pleiotropic effects, influencing redox homeostasis, thyroid hormone metabolism, and protecting from oxidative stress and inflammation. Serum selenium levels are reduced in the older population.
to investigate the association of serum selenium levels with all-cause mortality in a sample of community-dwelling older adults.
Design and Setting
Data are from the ‘Invecchiamento e Longevità nel Sirente’ (Aging and Longevity in the Sirente geographic area, ilSIRENTE) study, a prospective cohort study that collected information on individuals aged 80 years and older living in an Italian mountain community (n=347). The main outcome was risk of death after ten years of follow-up.
Participants and measurements
Participants were classified according to the median value of selenium (105.3 μg/L) in two groups: high selenium and low selenium.
A total of 248 deaths occurred during a 10-year follow-up. In the unadjusted model, low levels of selenium was associated with increased mortality (HR, 0.66; 95% CI 0.51-0.85). After adjusting for potential confounders the relationship remained significant (HR, 0.71; 95% CI 0.54-0.92).
Low serum levels of selenium are associated with reduced survival in elderly, independently of age and other clinical and functional variables.
Key wordsSelenium mortality frail elderly
- 13.Hughes DJ, Fedirko V, Jenab M, Schomburg L, Méplan C, Freisling H, Bueno-de-Mesquita HB, Hybsier S, Becker NP, Czuban M, Tjønneland A, Outzen M, Boutron-Ruault MC, Racine A, Bastide N, Kühn T, Kaaks R, Trichopoulos D, Trichopoulou A, Lagiou P, Panico S, Peeters PH, Weiderpass E, Skeie G, Dagrun E, Chirlaque MD, Sánchez MJ, Ardanaz E, Ljuslinder I, Wennberg M, Bradbury KE, Vineis P, Naccarati A, Palli D, Boeing H, Overvad K, Dorronsoro M, Jakszyn P, Cross AJ, Quirós JR, Stepien M, Kong SY, Duarte-Salles T, Riboli E, Hesketh JE. Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort. Int J Cancer. 2015 Mar 1;136(5):1149–61.CrossRefPubMedGoogle Scholar
- 16.Parizadeh SM, Moohebati M, Ghafoori F, Ghayour-Mobarhan M, Kazemi-Bajestani SM, Tavallaie S, Azimi-Nezhad M, Ferns GA. Serum selenium and glutathione peroxidase concentrations in Iranian patients with angiography-defined coronary artery disease. Angiology. 2009 Apr-May;60(2):186–91.CrossRefPubMedGoogle Scholar
- 19.Ray AL, Semba RD, Walston J, et al. Low serum selenium and total carotenoids predict mortality among older women living in the community: the Women’s Health and Aging Studies. J Nutr. 2006;136:172–176.Google Scholar
- 24.Morris JN, Fries BE, Bernabei R, et al. RAI–Home Care assessment manual. Washington, DC: InterRAI Coporation; 1996.Google Scholar
- 29.Combs GF Jr. Essentiality and toxicity of selenium: a critique of the recommended dietary allowance and the reference dose. In: Mertz W, Abernathy CO, Olin SS, eds. Risk assessment of essential elements. Washington, DC: ILSI Press, 1994:167–83.Google Scholar
- 33.Alehagen U, Aaseth J, Johansson P. Reduced Cardiovascular Mortality 10 Years after Supplementation with Selenium and Coenzyme Q10 for Four Years: Follow-Up Results of a Prospective Randomized Double-Blind Placebo-Controlled Trial in Elderly Citizens. PLoS One. 2015 Dec 1;10(12):e0141641.CrossRefPubMedPubMedCentralGoogle Scholar