Does patchouli oil change blood platelet monoamine oxidase-A activity of adult mammals?
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Patchouli oil, an essential aroma oil extracted from patchouli leaf during short-term exposure with five and ten drops either inhibited (at 1 or 2 h) or stimulated (at 4 h) the platelet MAO-A activity depending on the dosages of the aroma oil mainly due to inhibition or stimulation of its K m. The long-term 15 consecutive days exposure (with two or five drops) of patchouli oil, on the other hand, maximally stimulated the platelet MAO-A activity with five drops patchouli oil for 1 h exposure, but further continuation of its exposure with same doses (two or five drops) for 30 consecutive days significantly stimulated (with two drops) and inhibited (with five drops) the platelet MAO-A activity due to stimulation and inhibition respectively of its corresponding both K m and V max. These results thus suggest that this aroma oil exposure may modulate the blood platelet serotonergic regulation depending on the dose, duration, and conditions of exposure.
KeywordsBlood platelet Monoamine oxidase-A Patchouli oil
The authors are thankful to Prof. S. Sengupta, Department of Statistics, University of Calcutta for his kind help in statistical analysis of the data. We are also thankful to the University of Calcutta, Kolkata, India, the Indian Council of Medical Research, New Delhi, India, University Grants Commission, New Delhi, India for their financial help.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflicts of interest.
- 1.Rumya HG, Palanimuthu V, Rachna S (2013) An introduction to patchouli (Pogostemon cablin Benth.)—a medicinal and aromatic plant: it’s importance to mankind. Agric Eng Int CIGR J 15:243–250Google Scholar
- 2.Lawrence BM (1981) Patchouli oil: progress in essential oils. Perfum Flavorist 6:73–76Google Scholar
- 4.Yahya A, Yunus RM (2013) Influence of sample preparation and extraction time on chemical composition of steam distillation derived patchouli oil. Sci Verse Sci Direct Proc Eng 53:1–6Google Scholar
- 5.Healy MA, Aslam M (2002) Homoeopathic medicine and aromatherapy. In: Evans WC (ed) Pharmacognosy, 15th edn, pp 463–466Google Scholar
- 6.Bruna FMTA, Camila PB, Klinsmann C dos S, Lidiane NB, Vera LMR, José MS, Ana AHF, Ary FJ (2014) Effect of inhaling Cymbopogon martinii essential oil and geraniol on serum biochemistry parameters and oxidative stress in rats. Biochem Res Int (article ID 493183, 7 pages) Google Scholar
- 18.Young SN, Leyton M (2002) The role of serotonin in human mood and social interaction: insight from altered tryptophan levels. Pharmacol Biochem Behav 71:857–865Google Scholar
- 26.Huwig-Poppe Ch, Voderholzer U, Backhaus J, Riemann D, Konig A, Hohagen F (2012) The tryptophan depletion test: impact on sleep in healthy subjects and patients with obsessive–compulsive disorder. In: Huether G, Kochen W, Simat TJ, Steinhart H (eds) Tryptophan, serotonin and melatonin: basic aspects and application. Springer, New YorkGoogle Scholar
- 30.Oreland L, Hallman J (2009) Monoamine oxidase activity in relation to psychiatric disorders: the state of the art. Nordic J Psychiatry 42:95–105Google Scholar
- 31.Karim MF (2011) Optimum-range of distillation period (ORDP) per batch of different aromatic raw-materials are generally different, minimum and crop-specific as well: an outstanding fact for industrial application (abstr). In: Book of abstracts, third international congress on aromatic and medicinal plants (CIPAM-2011), Cagliari, p 74Google Scholar
- 36.Muchtaridi M, Tjiraresmi A, Febriyanti R (2015) Analysis of active compounds in blood plasma of mice after inhalation of cajuput essential oil (Melaleuca leucadendron L.) Indones J Pharm 26:219–227Google Scholar
- 39.Guyton AC, Hall JE (2011) Textbook of medical physiology, 12th edn. Saunders, Elsevier Press, New YorkGoogle Scholar
- 40.Meszaros Z, Borcsiozky D, Mate M, Tarcali J, Szombathy T, Mekes K, Magyar K (1998) Platelet MAO-B activity and serotonin content in patients with dementia: effect of age, medication and disease. Neurochem Res 23:863–868Google Scholar
- 47.Celada P, Sarrias MJ, Artigas F (1990) Serotonin and 5-hydroxyindoleacetic acid in plasma. Potential use as peripheral measures of MAO-A activity. J Neural Transm (Suppl) 32:149–154Google Scholar
- 48.Gerhard M (1974) Determination of Michaelis constants and inhibitor constants. In: Bergmeyer HU (ed) Methods of enzymatic analysis, vol 1, 2nd English edn. Academic Press, New York, pp 146–151Google Scholar
- 50.Baser KHC, Buchbauer G (2015) Handbook of essential oils: science, technology, and applications, 2nd edn. CRC Press, Boca Raton. ISBN: 781466590465.Google Scholar