Canola oil rich in oleic acid improves diastolic heart function in diet-induced obese rats
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Obesity is a leading cause of cardiovascular disease. It directly affects heart structure and function and contributes to heart failure. Diet is a major factor involved in the development of obesity along with genetic factors. We examined the effects of monounsaturated and polyunsaturated fatty acid-rich oils on cardiac structure and function in the diet-induced rodent model of obesity (DIO). Obese prone (OP) rats were fed a high-fat diet (HF; 55% of kcal) for 12 weeks; Sprague–Dawley rats fed commercial chow served as control. Echocardiography was performed to assess the cardiac structure and function in all rats at 12 weeks. OP rats fed the HF diet showed significant impairment in diastolic function compared to control rats. The HF diet containing high oleic canola oil significantly improved diastolic function of OP rats compared to the HF diet with lard. In conclusion, canola oil rich in oleic acid, when incorporated into an HF diet, prevents the development of diastolic dysfunction in DIO rats.
KeywordsDiet-induced obesity Edible oil Diastolic dysfunction
The infrastructural support was generously provided by the St. Boniface Hospital Research Foundation. We would also like to thank the staff of the R.O. Burrell Animal Facility at St. Boniface Research Centre for their help with animal care.
Compliance with ethical standards
Canola Products Research Fund, Canola/Flax Agri-Science Cluster and Canada-Manitoba (CT, PZ) and Agriculture and Agri-Food Canada (TN).
Conflict of interest
The authors report no conflict of interest.
The experimental protocols were approved by the University of Manitoba Animal Care Committee and are in agreement with the Canadian Council on Animal Care and Use of Experimental Animals.
This article does not contain any studies with human participants performed by any of the authors.
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