The effects of two-stage carotid occlusion on spatial memory and pro-inflammatory markers in the hippocampus of rats
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The purpose of this study was to evaluate the effects of cerebral hypoperfusion on cognitive ability, TNFα, IL1β and PGE2 levels in both hippocampi in a modified two-vessel occlusion model. Both common carotid arteries of adult male Wistar rats were permanently occluded with an interval of 1 week between occlusions. Learning and memory were significantly decreased after 1 month. This reduction was not significant after 2 months, which may be attributed to blood flow compensation. The TNFα level was significantly increased after 3 h and 1 day. IL1β was significantly increased after 1 day. After a week there was no significant difference in pro-inflammatory levels. Furthermore, there was no difference between right and left hippocampi. It is possible that TNFα and IL1β elevation initiates pathologic processes that contribute to memory impairment.
KeywordsCerebral hypoperfusion Inflammation Interleukins Spatial memory Hippocampus
This study was supported by Lorestan University of Medical Sciences as a Grant (No. 10/89) to Mehrnoush Moghaddasi. The authors are grateful to the directors in Razi Herbal Medicines Research Center for their assistance and collaboration.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
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