Résumé
Le carcinome hépatocellulaire fibrolamellaire (CHCF), est une variante histologique du carcinome hépatocellulaire (CHC). Il est rare, surtout associé à un bourgeon endobiliaire. C’est une pathologie du sujet jeune, sans prédominance de sexe. Il survient en dehors de toute hépatopathie. L’étiologie est inconnue et il n’y a pas de facteurs favorisants. L’alphafoetoprotéine (AFP) est normal. L’imagerie par résonnance magnétique (IRM) permet d’évoquer le diagnostic qui est confirmé par l’examen anatomopathologique. Le traitement repose sur la chirurgie: l’hépatectomie ou la transplantation hépatique. Le pronostic est bon à cause de sa resécabilité, de l’absence d’une cirrhose sous-jacente et du caractère jeune des patients. Nous rapportons le cas d’un jeune homme de 27 ans qui présente un carcinome hépatocellulaire fibrolamellaire avec bourgeon endobiliaire.
Abstract
Fibrolamellar hepatocellular carcinoma (FHC), is a histological alternative of carcinoma hepatocellular (CHC). It is rare, especially associated to an endobiliary bud. It’s a young subject pathology, without any sex prevalence. It occurs apart from any hepatopathy. The etiology is unknown and there are no supporting factors. The alphafetoprotein (AFP) is normal. The magnetic resonance imaging (MRI) makes it possible to evoke the diagnosis confirmed by the anatomopathological examination. The treatment rests on the surgery: hepatectomy or liver transplantation. The forecast is good because of its resecability, the absence of a subjacent cirrhosis and young nature of the patients. We report the case of a 27 years old man who presents fibrolamellar hepatocellular carcinoma with endobiliary bud.
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Références
El-Serag HB, Davila JA (2004) Is fibrolamellar carcinoma different from hepatocellular carcinoma? A US population-based study. Hepatology 39:798–803
Ebrahimi Daryani N, Ghanaati H, Aram S, et al (2007) Fibrolamellar Hepatocellular Carcinoma: A Case Report. Iran J Radiol 3:S3
Moore SW, Davidson A, Hadley GP, et al (2008) Malignant liver tumors in South African children: a national audit. World J Surg 32:1389–1395
González-Casas R, Capstan Milla C, Herrero A, et al (2010) Hepatocarcinoma Fibrolamelar: Caso Clinico en un adulto joven y revision del manejo clinic-terapeutico. Revista de la ACAD XXVI:47–51
Bralet MP, Régimbeau JM, Terris B (2000) Hepatocellular carcinoma occurring in nonfibrotic liver: epidemiologic and histopathologic analysis of 80 french cases. Hepatology 32:200–204
Moreno-Luna LE, Arrieta O, Leon-Rodriguez E (2005) Clinical and pathologic factors associate with survival in young adult patients with fibrolamellar hepatocarcinoma. BMC Cancer 5:142–149
Kanai T, Takabayashi T, Kawano Y, et al (2004) A case of postoperative recurrence of fibrolamellar hepatocellular carcinoma with increased vitamin B12 binding capacity in a young Japanese female. Jpn J Clin Oncol 34:346–351
Kakar S, Burgart LJ, Ferell LD (2005) Clinicopathologic features and survival in fibrolamellar carcinoma: comparison with conventional hepatocellular carcinoma with and without cirrhosis. Modern Pathol 18:1417–1423
Marrannes J, Gryspeerdt S, Haspeslagh M, et al (2005) Fibrolamellar hepatocellular carcinoma in 65-Year-Old Women: CT Features. Jbr Btr 88:237–240
Craig JR, Peters RL, Omata M (1980) Fibrolamellar carcinoma of the liver: a tumor of adolescents and young adults with distinctive Clinicopathologic features. Cancer 46:372–379
Stipa F, Yoon SS, Dematteo RP (2006) Outcome of patients with fibrolamellar hepatocellular carcinoma. Cancer 106:1331–1338
Ringe B, Wittekind C, Pichlmayr R (1992) Results of hepatic resection and transplantation for fibrolamellar carcinoma. Surg gynecol obstet 175:299–305
Hernandez-Castillo E, Mondragon-Sanchez R, Bernal-Maldonado R (2005) Hepatocellular carcinoma in the youth. A comparative analysis with hepatocellular carcinoma in adulthood. Hepato-Gastroentrology 52:903–907
El-Gazzaz G, Wong W, McMaster P (2000) Outcome of liver resection and transplantation for fibrolamellar hepatocellular carcinoma. Transpl Int 13:406–409
Soyer P, Roche A, Levesque M (1992) Fibrolamellar hepatocellular carcinoma: report of four cases treated by locoregional intraarterial therapy. Jbr Btr 75:463–468
Gornicka B, Ziarkiewicz B, Wasiutynski A (2005) Carcinoma, a fibrolamellar variant immunohistochemical analysis of 4 cases. Hepato-Gastroentrology 52:519–523
Galati G, Saran RK (2009) Fine needle aspiration cytology of fibrolamellar hepatocellular carcinoma: Recognizing the oncocytic hepatocyte. Indian J Pathol Microbiol 52:288–289
Da Ines D, Lannarex V, Petitcolin V, et al (2009) Fibrolamellar hepatocellular carcinoma in a patient with chronic viral B hepatitis. Gastroenterol Clin Biol 33:382–386
Ichikawa T, Federle MP, Grazioli L, et al (1999) Fibrolamellar hepatocellular carcinoma: imaging and pathologic findings in 31 recent cases. Radiology 213:352–361
Terzis I, Haritanti A, Economou I (2010) Fibrolamellar hepatocellular carcinoma: a case report with distinct radiological features. J Gastrointest Canc 41:2–5
Brandt DJ, Johnson CD, Stephens DH (1988) Imaging of fibrolamellar hepatocellular carcinoma. Am J Roentgenol 151:295–299
Soyer P, Roche A, Levesque M, et al (1991) CT of fibrolamellar hepatocellular carcinoma. J Comput Assist Tomogr 15:533–538
Berman MA, Burnham JA, Sheahan DG (1988) Fibrolamellar carcinoma of the liver: an immunohistochemical study of nineteen cases and a review of the literature. Hum Pathol 19:784–794
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Traoré, A., Togo, A., Yaribakht, S. et al. Hépatocarcinome fibrolamellaire avec bourgeon endobiliaire : cas clinique. J Afr Cancer 4, 190–194 (2012). https://doi.org/10.1007/s12558-012-0216-y
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DOI: https://doi.org/10.1007/s12558-012-0216-y