Abstract
Heart failure (HF) is a complication of multiple cardiac diseases and is characterized by impaired contractile and electric function. Patients with HF are not only limited by reduced contractile function but are also prone to life-threatening ventricular arrhythmias. HF itself leads to remodeling of ion channels, gap junctions, and intracellular calcium handling abnormalities that in combination with structural remodeling, e.g., fibrosis, produce a substrate for an arrhythmogenic disorders. Not only ventricular life-threatening arrhythmias contribute to increased morbidity and mortality but also atrial arrhythmias, especially atrial fibrillation (AF), are common in HF patients and contribute to morbidity and mortality. The distinct ion channel remodeling processes in HF and in channelopathies associated with HF will be discussed. Further basic research and clinical studies are needed to identify underlying molecular pathways of HF pathophysiology to provide the basis for improved patient care and individualized therapy based on individualized ion channel composition and remodeling.
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This work was supported in part by grants from the University of Heidelberg, Faculty of Medicine (Physician Scientist Scholarship to A.K.R.), from the German Cardiac Society (DGK Scholarship to A.K.R) from the German Cardiac Society and the Hengstberger Foundation (Klaus-Georg and Sigrid Hengstberger Scholarship to D.T.), from the German Heart Foundation/German Foundation of Heart Research (F/08/14 to D.T.), from the Joachim Siebenreicher Foundation (to D.T.), and from the Ministry of Science, Research and the Arts Baden-Wuerttemberg (Sonderlinie Medizin to D.T.).
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D.T. reports receiving lecture fees/honoraria from Bayer Vital, Boehringer Ingelheim, Bristol-Myers Squibb, Daiichi Sankyo, Medtronic, Pfizer Pharma, Sanofi-Aventis, St. Jude Medical, and ZOLL CMS, and research grant support from Daiichi Sankyo.
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This article is part of a Special Issue on “Heart Failure Due to Non-Myofibrillar Defects” edited by Elisabeth Ehler and Katja Gehmlich.
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Rahm, AK., Lugenbiel, P., Schweizer, P.A. et al. Role of ion channels in heart failure and channelopathies. Biophys Rev 10, 1097–1106 (2018). https://doi.org/10.1007/s12551-018-0442-3
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DOI: https://doi.org/10.1007/s12551-018-0442-3