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Biophysical Reviews

, Volume 10, Issue 3, pp 809–824 | Cite as

Aqueous ionic liquids in comparison with standard co-solutes

Differences and common principles in their interaction with protein and DNA structures
  • Ewa Anna Oprzeska-Zingrebe
  • Jens Smiatek
Review

Abstract

Ionic liquids (ILs) are versatile solvents for a broad range of biotechnological applications. Recent experimental and simulation results highlight the potential benefits of dilute ILs in aqueous solution (aqueous ILs) in order to modify protein and DNA structures systematically. In contrast to a limited number of standard co-solutes like urea, ectoine, trimethylamine-N-oxide (TMAO), or guanidinium chloride, the large amount of possible cation and anion combinations in aqueous ILs can be used to develop tailor-made stabilizers or destabilizers for specific purposes. In this review article, we highlight common principles and differences between aqueous ILs and standard co-solutes with a specific focus on their underlying macromolecular stabilization or destabilization behavior. In combination with statistical thermodynamics theories, we present an efficient framework, which is used to classify structure modification effects consistently. The crucial importance of enthalpic and entropic contributions to the free energy change upon IL-assisted macromolecular unfolding in combination with a complex destabilization mechanism is described in detail. A special focus is also set on aqueous IL-DNA interactions, for which experimental and simulation outcomes are summarized and discussed in the context of previous findings.

Keywords

Ionic liquids Proteins DNA Co-solutes Kirkwood-Buff theory 

Notes

Acknowledgements

The authors acknowledge helpful discussions with Diddo Diddens, Volker Lesch, Andreas Heuer, Hans-Joachim Galla, Julian Michalowsky, Miriam Kohagen, Frank Uhlig, Johannes Zeman, Maria Fyta, Takeshi Kobayashi, Anand Narayanan Krishnamoorthy, Samantha Micciulla, Martin Grininger, Wilhelm-Maximilian Hützler, Marc-Benjamin Hahn, Tihomir Solomun, Heinz Sturm, Martin Schroer, Christian Schröder, and Christian Holm.

Funding information

This work was funded by the Deutsche Forschungsgemeinschaft through the Sonderforschungsbereich 716 (SFB 716)

Compliance with ethical standards

Conflict of interest

Ewa Anna Oprzeska-Zingrebe declares that she has no conflicts of interest. Jens Smiatek declares that he has no conflicts of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Institute for Computational PhysicsUniversity of StuttgartStuttgartGermany
  2. 2.Helmholtz Institute Münster: Ionics in Energy Storage (HI MS – IEK 12)Forschungszentrum Jülich GmbHMünsterGermany

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