Protein folding and assembly can be manipulated in in vitro systems by co-solvents at high concentrations. A number of co-solvents that enhance protein stability and assembly have been shown to be excluded from the protein surface. Such co-solvent exclusion has been demonstrated by dialysis experiments and shown to be correlated with their effects on protein stability and assembly.
KeywordsProtein folding and assembly In vitro systems Co-solvents Preferentially excluded co-solvents Dialysis equilibrium
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Conflict of interest
Tsutomu Arakawa declares that he has no conflicts of interest.
This article does not contain any studies with human participants or animals performed by the author.
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