ADHD-juvenile bipolar disorder: mimics and chameleons!

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Author declares no conflict of interests in the past 36 months.


  1. 1.
    Campbell M, Cueva JE. Psychopharmacology in child and adolescent psychiatry: a review of the past seven years: part II. J Am Acad Child Adolesc Psychiatry. 1995;34:1262–72.CrossRefPubMedGoogle Scholar
  2. 2.
    State RC, Frye MA, Althsuler LL, Strober M, DeAntonio M, Hwang S, et al. Chart review of the impact of attention-deficit/hyperactivity disorder comorbidity on response to lithium or divalproex sodium in adolescent mania. J Clin Psychiatry. 2004;65:1057–63.CrossRefPubMedGoogle Scholar
  3. 3.
    Kim EY, Milkowitz DJ. Childhood mania, attention deficit hyperactivity disorder and conduct disorder: a critical review of diagnostic dilemmas. Bipolar Disord. 2002;4:215–25.CrossRefPubMedGoogle Scholar
  4. 4.
    Biederman J, Faraone SV, Spencer T, Wilens T, Mick E, Lapey KA. Gender differences in a sample of adults with attention deficit hyperactivity disorder. Psychiatry Res. 1994;53:13–29.CrossRefPubMedGoogle Scholar
  5. 5.
    Singh MK, DelBello MP, Kowatch RA, Strakowski SM. Co-occurrence of bipolar and attention-deficit hyperactivity disorders in children. Bipolar Disord. 2006;8:710–20.CrossRefPubMedGoogle Scholar
  6. 6.
    Kowatch RA, Youngstrom EA, Danielyan A, Findling RL. Review and meta-analysis of the phenomenology and clinical characteristics of mania in children and adolescents. Bipolar Disord. 2005;7:483–96.CrossRefPubMedGoogle Scholar
  7. 7.
    DelBello MP, Adler CM, Amicone J, Mills NP, Shear PK, Warner J, et al. Parametric neurocognitive task design: a pilot study of sustained attention in adolescents with bipolar disorders. J Affect Disord. 2004;82(Suppl. 1):S79–88.CrossRefPubMedGoogle Scholar
  8. 8.
    Perlis RH, Miyahara S, Marangell LB, Wisniewski SR, Ostacher M, DelBello MP, et al. Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD). Biol Psychiatry. 2004;55:875–81.CrossRefPubMedGoogle Scholar
  9. 9.
    Henin A, Biederman J, Mick E, Sachs GS, Hirshfeld-Becker DR, Siegel RS, et al. Psychopathology in the offspring of parents with bipolar disorder: a controlled study. Biol Psychiatry. 2005;58:554–61.CrossRefPubMedGoogle Scholar
  10. 10.
    Carlson GA, Loney J, Salisbury H, Kramer JR, Arthur C. Stimulant treatment in young boys with symptoms suggesting childhood mania: a report from a longitudinal study. J Child Adolesc Psychopharmacol. 2000;10:175–84.CrossRefPubMedGoogle Scholar
  11. 11.
    Geller B, Zimerman MA, Williams M, DelBello MP, Bolhofner K, Craney JL, et al. DSM-IV mania symptoms in a prepubertal and early adolescent bipolar disorder phenotype compared to attention-deficit hyperactive and normal controls. J Child Adolesc Psychopharmacol. 2002;12:11–25.CrossRefPubMedGoogle Scholar
  12. 12.
    Mick E, Biederman J, Pandina G, Faraone SV. A preliminary meta-analysis of the child behavior checklist in pediatric bipolar disorder. Biol Psychiatry. 2003;53:1021–7.CrossRefPubMedGoogle Scholar
  13. 13.
    Faraone SV, Althoff RR, Hudziak JJ, et al. The CBCL predicts DSM bipolar disorder in children: a receiver operating characteristic curve analysis. Bipolar Disord. 2005;7:518–24.CrossRefPubMedGoogle Scholar
  14. 14.
    Biederman J, Petty CR, Monuteaux MC, Evans M, Parcell T, Faraone SV, et al. The child behaviour checklist-pediatric bipolar disorder profile predicts a subsequent diagnosis of bipolar disorder and associated impairments in ADHD youth growing up: a longitudinal analysis. J Clin Psychiatry. 2009;70:732–40.CrossRefPubMedPubMedCentralGoogle Scholar
  15. 15.
    Faraone SV, Biederman J, Mennin D, Russell R. Bipolar and antisocial disorders among relatives of ADHD children: parsing familial subtypes of illness. Am J Med Genet. 1998;81:108–16.CrossRefPubMedGoogle Scholar
  16. 16.
    Wilens T, Biederman J, Wozniack J, Gunawardene S, Wong J, Monuteaux M. Can adults with attention-deficit hyperactivity disorder be distinguished from those with comorbid bipolar disorder: findings from a sample of clinically referred adults. Biol Psychiatry. 2003;54:1–8.CrossRefPubMedGoogle Scholar
  17. 17.
    Naguy A. Psychopharmacotherapy of attention-deficit/hyperactivity disorder complex presentations. Pediatr Neurol. In Press 2017.Google Scholar
  18. 18.
    Wilens TE, Prince JB, Spencer T, Van Patten SL, Doyle R, Girard K, Hammarness P, et al. An open trial of bupropion for the treatment of adults with attention deficit hyperactivity disorder and bipolar disorder. Biol Psychiatry. 2003;54:9–16.CrossRefPubMedGoogle Scholar
  19. 19.
    Hah M, Chang K. Atomoxetine for the treatment of attention-deficit/hyperactivity disorder in children and adolescents with bipolar disorders. J Child Adolesc Psychopharmacol. 2005;15:996–1004.CrossRefPubMedGoogle Scholar
  20. 20.
    Jaworowski S, Benarroch F, Gross-Tsur V. Concomitant use of atomoxetine and OROS-methylphenidate in a 10-year-old child suffering from attention-deficit/hyperactivity disorder with comorbid bipolar disorder and Tourette syndrome. J Child Adolesc Psychopharmacol. 2006;16:365–70.CrossRefPubMedGoogle Scholar

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© Children's Hospital, Zhejiang University School of Medicine 2018

Authors and Affiliations

  1. 1.Al-Manara CAP Centre, KCMHShuwaikhKuwait

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