World Journal of Pediatrics

, Volume 13, Issue 1, pp 49–56 | Cite as

Analysis of the characteristics and management of critical values in a newborn tertiary center in China

  • Zheng-Li Wang
  • Li-Zhong Du
  • Yi-Yu Chen
  • Lu-Quan Li
  • Qi Lu
  • Ying Liu
  • Lu-Ying Cao
  • Yu He
  • Jia-Lin Yu
Original article



Critical value reporting has been widely adopted by hospitals throughout the world, but there were few reports about neonatal critical values. This study aimed to analyze characteristics of the neonatal critical values considered at our center and to provide information on improving neonatal intensive care.


A retrospective study of critical values at a newborn tertiary center in China was conducted to assess neonatal critical values according to test, distribution, reporting time, patient outcome and the impact to the therapy.


In total, 926 critical values were recorded. Overall, 66.52% (616/926) of the items were reported within 24 hours of admission, 50.28% (465/926) during duty times and 54.75% (507/926) in the neonatal intensive care unit (NICU). The routine coagulation test was the most frequent source of critical values. Electrocardiography, blood gas analysis and therapeutic drug monitoring of drug levels were associated with the highest rates of treatment intervention (100%); routine coagulation tests were the lowest (23.14%). Sample quality was the main cause of false-positive critical values.


The incidence of neonatal critical values peaked during the first 24 hours post-admission and during duty periods. Each newborn center needs to enact rapid treatment guidelines to address common critical values in order to facilitate clinical interventions. Periodically reviewing critical values could help to optimize clinical practices.

Key words

critical care critical value management strategies newborn 


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Copyright information

© Children's Hospital, Zhejiang University School of Medicine and Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Zheng-Li Wang
    • 1
  • Li-Zhong Du
    • 2
  • Yi-Yu Chen
    • 1
  • Lu-Quan Li
    • 1
  • Qi Lu
    • 1
  • Ying Liu
    • 1
  • Lu-Ying Cao
    • 1
  • Yu He
    • 1
  • Jia-Lin Yu
    • 1
    • 3
  1. 1.Department of Neonatology, Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and DisordersKey Laboratory of Pediatrics in Chongqing and Chongqing International Science and Technology Cooperation Center for Child Development and DisordersChongqingChina
  2. 2.Department of Neonatology, Children’s HospitalZhejiang University School of MedicineHangzhouChina
  3. 3.ChongqingChina

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