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Effect of prenatal antioxidant intake on infants’ respiratory infection is modified by a CD14 polymorphism

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Abstract

Background

Prenatal maternal diet may influence disease susceptibility in offspring with specific genetic backgrounds. We hypothesized that interactions between prenatal antioxidant intake and polymorphisms in immunity genes influence respiratory tract infection (RTI) susceptibility in infants at 12 months of age.

Methods

This study included 550 infants. In the Cohort for Childhood Origin of Asthma and Allergic Diseases (COCOA) birth cohort study, prenatal maternal diet was assessed by administering a food frequency questionnaire. Infants’ cord blood was genotyped for CD14 (rs2569190), TLR4 (rs1927911), and GSDMB (rs4794820) polymorphisms by the TaqMan method.

Results

Higher prenatal intake of total fruit and vegetables (FV) was associated with the decreased risk of RTI in offspring (P-trend=0.0430). In children with TT genotype at rs2569190, a higher prenatal intake of vitamins A and C, fruits, and total FV decreased RTI risk (P-trend <0.05), while in infants with TC+CC genotype, a higher prenatal intake of fruit increased RTI risk (P-trend <0.05). When analyzing the 3 genotypes, children with TT genotype at rs2569190 were more protected against RTIs compared with those with CC genotype with respect to vitamin C and fruits [odds ratio (OR)=5.04 and OR=10.30, respectively]. In children with CC genotype at rs1927911, RTI risk showed a dose–response association with a higher prenatal intake of vitamin C (P for interaction<0.05). A higher prenatal intake of fruits and total FV reduced RTI risk in infants with GA+AA genotype of rs4794820 (P for interaction<0.05).

Conclusions

Prenatal antioxidant intake may reduce RTI risk in infants and this relationship may be modified by CD14, TLR4, and GSDMB polymorphisms.

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Acknowledgements

We would like to gratefully and sincerely thank Dr. Ja-Young Kwon, Suk-Joo Choi, Kyung-Ju Lee, Hee Jin Park, Hye-Sung Won, Mi-Jin Kang, Ho-Sung Yu, Hyung Young Kim, Ju-Hee Seo, Byoung-Ju Kim, Hyo-Bin Kim, and So-Yeon Lee for their participation in this study.

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Authors and Affiliations

  1. ASEAN Institute for Health Development, Mahidol University, Salaya, Phutthamonthon, Nakhonpathom, Thailand

    Seo Ah Hong

  2. Department of Pediatrics, Inje University Haeundae Paik Hospital, Busan, Korea

    Eun Lee

  3. Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Korea

    Soo-Jong Hong

  4. Department of Food and Nutrition, Research Institute of Human Ecology, Kyung Hee University, Seoul, Korea

    Sung Ok Kwon & Se-Young Oh

  5. Department of Pediatrics, Severance Children’s Hospital, College of Medicine, Yonsei University, Seoul, Korea

    Kyung Won Kim

  6. Department of Pediatrics, CHA Medical Center, CHA University School of Medicine, Seoul, Korea

    Youn Ho Shin

  7. Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

    Kang Mo Ahn

  8. Division of Allergy and Respiratory Diseases, Korea National Institute of Health, Osong Health Technology Administration Complex, Seoul, Korea

    Eun-Jin Kim & Jeom-Gyu Lee

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  1. Seo Ah Hong
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Correspondence to Soo-Jong Hong.

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Hong, S.A., Lee, E., Kwon, S.O. et al. Effect of prenatal antioxidant intake on infants’ respiratory infection is modified by a CD14 polymorphism. World J Pediatr 13, 173–182 (2017). https://doi.org/10.1007/s12519-016-0054-6

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  • DOI: https://doi.org/10.1007/s12519-016-0054-6

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