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Neuropraxis

, Volume 22, Issue 3, pp 92–97 | Cite as

Op zoek naar biomarkers van de alcoholkater

  • Marlou Mackus
  • Chantal G. Terpstra
  • Aurora J. A. E. van de Loo
  • Joris C. Verster
Artikel
  • 34 Downloads

Samenvatting

De alcoholkater wordt gedefinieerd als de combinatie van mentale en fysieke symptomen die ervaren worden de dag na een stevige drinksessie, die start wanneer de bloedalcoholconcentratie de nulwaarde nadert. Dit artikel betreft een naturalistisch opgezet onderzoek naar de samenhang tussen de ernst van de alcoholkater en mogelijke biomarkers voor een alcoholkater, namelijk de urineconcentraties van ethanol, methanol, ethylglucuronide (EtG) en ethylsulfaat (EtS). Aan dit onderzoek deden 36 gezonde sociale drinkers mee (18 katersensitieve en 18 katerresistente drinkers). Van alle deelnemers werden op een postalcoholdag en op de controledag de urineconcentraties van ethanol, methanol, EtG en EtS bepaald. Deelnemers konden zelf hun controledag en postalcoholdag bepalen, evenals de hoeveelheid alcohol die zij consumeerden. Vervolgens is de correlatie tussen de urineconcentratie en de ernst van de alcoholkater berekend en gescoord op een schaal van 0 (afwezig) tot 10 (extreem erg). De correlatie tussen de ernst van de alcoholkater en de urineconcentraties waren niet significant. Wel correleerden de ethanol-urineconcentraties significant met de ernst van de alcoholkater. Verder onderzoek is nodig naar de pathologie van de alcoholkater en mogelijke biomarkers die significant correleren met de ernst van de kater.

Trefwoorden

alcohol kater biomarker ethanol methanol ethylglucuronide ethylsulfaat 

Notes

Declaration of interest

J. Verster has received grants/research support from the Dutch Ministry of Infrastructure and the Environment, Janssen Research and Development, Nutricia, Red Bull, Sequential, and Takeda, and has acted as a consultant for the Canadian Beverage Association, Centraal Bureau Drogisterijbedrijven, Clinilabs, Coleman Frost, Danone, Deenox, Eisai, Janssen, Jazz, Purdue, Red Bull, Sanofi-Aventis, Sen-Jam Pharmaceutical, Sepracor, Takeda, Transcept, Trimbos Institute, Vital Beverages, and ZBiotics. The other authors have no potential conflicts of interest to disclose.

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Copyright information

© Bohn Stafleu van Loghum is een imprint van Springer Media B.V., onderdeel van Springer Nature 2018

Authors and Affiliations

  • Marlou Mackus
    • 1
  • Chantal G. Terpstra
    • 2
  • Aurora J. A. E. van de Loo
    • 1
    • 3
  • Joris C. Verster
    • 1
    • 2
    • 3
  1. 1.Divisie Farmacologie, Utrecht Institute for Pharmaceutical SciencesUniversiteit UtrechtUtrechtNederland
  2. 2.Centre for Human PsychopharmacologySwinburne UniversityMelbourneAustralië
  3. 3.Institute for Risk Assessment Sciences (IRAS)Universiteit UtrechtUtrechtNederland

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