Table 1 Prospective randomized clinical trials proposed to evaluate the utility of cardiac mIBG imaging in patients with congestive heart failure

From: The quest to improve sudden cardiac death prediction using sympathetic innervation scintigraphy: Chasing a mirage?

Studies Study aims Status
ADMIRE-ICD: international study to determine if AdreView heart function scan can be used to identify patients with mild or moderate heart failure (HF) that benefit from implanted medical device (NCT02656329) To demonstrate the efficacy of cardiac mIBG imaging for appropriately guiding the decision of ICD implantation, in heart failure patients (35% ≥ LVEF ≥ 25%) Suspended due to recruitment rate
MISTIC: mIBG scintigraphy as a tool for selecting patients requiring implantable cardioverter defibrillator (NCT01185756) To assess if cardiac innervation in patients with heart failure can help better select candidates for an implantable cardioverter defibrillator Active; not recruiting
PET/CT With 18F-FDG: does it optimize the 123I-mIBG imaging results in the search for discriminating factors for the implementation of an implantable defibrillator? (NCT01258283) To determine if the number of discordant segments (mismatch) differs between patients with and without severe arrhythmia Terminated due to slow recruitment
Cardiac resynchronization and iodine meta-iodobenzylguanidine (mIBG) imaging (NCT01522378) To determine whether response to cardiac resynchronization therapy is associated with improvement in cardiac sympathetic innervation Terminated
  1. Data in the table abstracted from, last accessed on April 15th, 2019