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State-of-the-art radionuclide imaging in cardiac transthyretin amyloidosis

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Journal of Nuclear Cardiology Aims and scope

Abstract

Cardiac amyloidosis, once considered untreatable, is now gaining well-deserved attention due to advances in imaging and the recent approval of targeted breakthrough therapies. In this paper, we discuss the role of radionuclide imaging in the evaluation and management of patients with the most common form of amyloidosis—cardiac transthyretin amyloidosis (ATTR). We provide a comprehensive summary of the literature interspersed with our institutional experience as appropriate, to deliver our perspective.

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Disclosures

Dr. Singh has no disclosures. Dr. Falk has research grants from Ionnis, Alnylam, Glaxo Smith Kline and Pfizer. He serves as a consultant for Proclara. Dr. Di Carli has research grant from Spectrum Dynamics and Gilead, and consulting fees from Sanofi and GE. Dr. Dorbala served as a consultant with Advanced Accelerator Applications, General Electric and Proclara. Dr. Rapezzi has research grants from Pfizer and consulting fees from Pfizer and Alnylam.

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Authors and Affiliations

  1. Division of Nuclear Medicine and Department of Radiology, Brigham and Women’s Hospital, Boston, MA, 2115, USA

    Vasvi Singh MD, Marcelo F. Di Carli MD, Marie Kijewski PhD & Sharmila Dorbala MD

  2. Cardiac Amyloidosis Program, Brigham and Women’s Hospital, Boston, MA, 2115, USA

    Rodney Falk MD & Sharmila Dorbala MD

  3. Cardiology, Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy

    Claudio Rapezzi MD

  4. Cardiac Amyloidosis Program, Cardiovascular Division, Department of Medicine, Heart and Vascular Center, Division of Nuclear Medicine and Department of Radiology, Brigham and Women’s Hospital and Harvard Medical School, 75 Francis St, Boston, MA, 02115, USA

    Sharmila Dorbala MD

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  1. Vasvi Singh MD
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  2. Rodney Falk MD
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  3. Marcelo F. Di Carli MD
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Correspondence to Sharmila Dorbala MD.

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The authors of this article have provided a PowerPoint file, available for download at SpringerLink, which summarises the contents of the paper and is free for re-use at meetings and presentations. Search for the article DOI on SpringerLink.com.

Funding

Dr. Dorbala is supported by NIH RO1 Grant (RO1 HL 130563) and the American Heart Association Grant (AHA 16 CSA 2888 0004). Dr. Falk is supported by NIH RO1 Grant (RO1 HL 130563).

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Singh, V., Falk, R., Di Carli, M.F. et al. State-of-the-art radionuclide imaging in cardiac transthyretin amyloidosis. J. Nucl. Cardiol. 26, 158–173 (2019). https://doi.org/10.1007/s12350-018-01552-4

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