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Impact of respiratory motion correction on SPECT myocardial perfusion imaging using a mechanically moving phantom assembly with variable cardiac defects

  • Original Article
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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

The aim of this study was to determine the impact of respiratory motion correction on SPECT MPI and on defect detection using a phantom assembly.

Methods

SPECT/CT data were acquired using an anthropomorphic phantom with inflatable lungs and with an ECG beating and moving cardiac compartment. The heart motion followed the respiratory pattern in the cranio-caudal direction to simulate normal or deep breathing. Small or large transmural defects were inserted into the myocardial wall of the left ventricle. SPECT/CT images were acquired for each of the four respiratory phases, from exhale to inhale. A respiratory motion correction was applied using an image-based method with transformation parameters derived from the SPECT data by a non-rigid registration algorithm. A report on defect detection from two physicians and a quantitative analysis on MPI data were performed before and after applying motion correction.

Results

Respiratory motion correction eliminated artifacts present in the images, resulting in a uniform uptake and reduction of motion blurring, especially in the inferior and anterior regions of the LV myocardial walls. The physicians’ report after motion correction showed that images were corrected for motion.

Conclusions

A combination of motion correction with attenuation correction reduces artifacts in SPECT MPI. AC-SPECT images with and without motion correction should be simultaneously inspected to report on small defects.

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Abbreviations

SPECT:

Single-photon emission computed tomography

CT:

Computed tomography

AC:

Attenuation correction

MPI:

Myocardial perfusion imaging

PLC:

Programmable logic controller

MC:

Motion correction

LV:

Left ventricle

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Acknowledgments

We gratefully acknowledge the Nuclear Medicine Department of the Nicosia General Hospital (Andreas Mormoris, Chariklia Christodoulou, Lambros Lambrou, Charoula Charalambous) for helping in acquisitions. We also thank Guy’s and St Thomas Hospitals NHS Foundation Trust (Steve Turner, Bill Stevens) for optimizing the cardiac holder. The Project ΥΓΕΙΑ/ΔΥΓΕΙΑ/0311(ΒΙΕ)/27, with Host Organization the Frederick Research Center and Partner Organizations the Cyprus Ministry of Health and the King’s College London, was co-financed by the European Regional Development Fund and the Republic of Cyprus through the Research Promotion Foundation.

Disclosure

The authors declared that they have no conflict of interest.

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Authors and Affiliations

  1. Division of Imaging Sciences and Biomedical Engineering, King’s College London, London, United Kingdom

    Irene Polycarpou PhD, Paul K. Marsden PhD & Lefteris Livieratos PhD

  2. Department of Health Sciences, European University Cyprus, Nicosia, Cyprus

    Irene Polycarpou PhD

  3. Frederick Research Center, Nicosia, Cyprus

    Isabelle Chrysanthou-Baustert PhD & Yiannis Parpottas PhD

  4. Department of Nuclear Medicine, Limassol General Hospital, Limassol, Cyprus

    Ourania Demetriadou MD

  5. General Department (Physics-Mathematics), Frederick University, Nicosia, Cyprus

    Yiannis Parpottas PhD

  6. Department of Nuclear Medicine, Nicosia General Hospital, Nicosia, Cyprus

    Christoforos Panagidis MD

  7. Guy’s and St Thomas’ Hospitals NHS Foundation Trust, London, United Kingdom

    Lefteris Livieratos PhD

Authors
  1. Irene Polycarpou PhD
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  2. Isabelle Chrysanthou-Baustert PhD
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  3. Ourania Demetriadou MD
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  4. Yiannis Parpottas PhD
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  5. Christoforos Panagidis MD
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  6. Paul K. Marsden PhD
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  7. Lefteris Livieratos PhD
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Correspondence to Irene Polycarpou PhD.

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Polycarpou, I., Chrysanthou-Baustert, I., Demetriadou, O. et al. Impact of respiratory motion correction on SPECT myocardial perfusion imaging using a mechanically moving phantom assembly with variable cardiac defects. J. Nucl. Cardiol. 24, 1216–1225 (2017). https://doi.org/10.1007/s12350-015-0323-0

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  • DOI: https://doi.org/10.1007/s12350-015-0323-0

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