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Journal of Nuclear Cardiology

, Volume 24, Issue 1, pp 43–52 | Cite as

Relationships between left ventricular asynchrony and myocardial blood flow

  • Andrew Van Tosh
  • John R. Votaw
  • C. David Cooke
  • Nathaniel Reichek
  • Christopher J. Palestro
  • Kenneth J. Nichols
Original Article

Abstract

Objective

82Rb PET protocols enable determination of left ventricular asynchrony (LVAS) at rest and stress, along with myocardial blood flow (MBF). We hypothesized that in patients with resting LVAS, MBF differs between those with stress-induced LVAS improvement and those with stress-induced LVAS deterioration.

Methods

We retrospectively analyzed 82Rb rest/regadenoson stress PET studies of 195 patients evaluated for known or suspected coronary artery disease. MBF was computed from first-pass data; function and relative perfusion were computed from myocardial equilibrium data. LVAS was defined as phase contraction bandwidth (BW) above 82Rb gender-specific normal limits, with changes defined as BW moving into or out of normal ranges.

Results

Among the 195 patients, 64 had LVAS at rest, of whom 13 reverted to normal and 51 continued to have LVAS with stress. Patients who did not improve had lower stress MBF (1.04 ± 0.69 vs 1.58 ± 0.67, p = .02) and coronary flow reserve (1.94 ± 1.16 vs 3.04 ± 1.22, p = .01) than those who did improve. ROC analysis indicated that the parameter most strongly associated with improvement in asynchrony for patients with resting LVAS was reduction in MBF heterogeneity (ROC area (accuracy) = 84%, sensitivity = 92%, and specificity = 67%).

Conclusion

LVAS is highly correlated with MBF and CVR, with stress-induced improvement in synchronicity most strongly associated with improved MBF homogeneity.

Keywords

PET/CT asynchrony coronary flow reserve rubidium isotopes 

Abbreviations

CFR

Coronary flow reserve

CRT

Cardiac resynchronization therapy

CVR

Coronary vascular resistance

EDV

End-diastolic volume

EF

Ejection fraction

ESV

End-systolic volume

LV

Left ventricle

LVAS

Left ventricular asynchrony

MBF

Myocardial blood flow

OSEM

Ordered subset expectation maximization

Notes

Disclosures

Co-authors John R. Votaw, C. David Cooke, and Kenneth J. Nichols participate in royalties from Syntermed, Inc., in relation to some of the algorithms discussed in this manuscript. This work was supported in part by a Grant from NIH, R01HL085417-04.

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Copyright information

© American Society of Nuclear Cardiology 2015

Authors and Affiliations

  • Andrew Van Tosh
    • 1
    • 4
  • John R. Votaw
    • 2
  • C. David Cooke
    • 2
  • Nathaniel Reichek
    • 1
  • Christopher J. Palestro
    • 3
  • Kenneth J. Nichols
    • 3
  1. 1.Research DepartmentSt. Francis HospitalRoslynUSA
  2. 2.Department of RadiologyEmory UniversityAtlantaUSA
  3. 3.Division of Nuclear Medicine and Molecular ImagingNorth Shore - Long Island Jewish Health SystemManhasset & New Hyde ParkUSA
  4. 4.Division of Cardiovascular ResearchSt. Francis Hospital - The Heart CenterRoslynUSA

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