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Relation of early post-stress left ventricular dyssynchrony and the extent of angiographic coronary artery disease

  • Original Article
  • Published:
Journal of Nuclear Cardiology Aims and scope

Abstract

Background

Previous studies showed different dyssynchrony patterns between ischemic and normal myocardium at early post-stress using Tl-201 gated SPECT myocardial perfusion imaging (MPI). The aim of this study was to assess the relation of stress-induced dyssynchrony and the extent of angiographic coronary artery disease (CAD).

Methods and Results

The MPI images of 144 patients were retrospectively analyzed. With ≥70% stenosis as the criteria of CAD, 57 had no CAD, 32 had 1-vessel disease, 36 had 2-vessel disease, and 19 had 3-vessel disease, respectively. LV global and territorial dyssynchrony parameters were measured by the phase analysis from stress/rest Tl-201 SPECT MPI and compared between stress and rest among the patient groups. The patients with multi-vessel CAD had significantly more global dyssynchrony than the patients without ≥70% stenosis at stress. The patients with multi-vessel CAD showed significantly more global and territorial dyssynchrony on stress images than on rest. More patients with 3-vessel CAD were correctly classified as multi-vessel disease, when combining both visual interpretation and dyssynchrony assessment.

Conclusion

The patients with multi-vessel CAD had significantly more global and territorial dyssynchrony at early post-stress than at rest. Such quantitative measures of myocardial stunning may assist in the diagnosis of multi-vessel CAD.

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Acknowledgments

This study was supported in part by a research grant from Changhua Christain Hospital (102-CCH-IRP-060) and an NIH Grant (1R01HL094438, PI: Ji Chen, PhD).

Disclosure

Dr Ji Chen receives royalties from the sale of Emory Cardiac Toolbox with SyncTool. The terms of this arrangement have been reviewed and approved by Emory University in accordance with its conflict-of-interest practice.

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, Changhua Christian Hospital, Changhua, Taiwan

    Wen-Sheng Huang MD

  2. Department of Cardiology, Changhua Christian Hospital, 135 Nan-Shiao Street, 500, Changhua, Taiwan

    Ching-Hui Huang MD & Cheng-Liang Lee MD

  3. Division of Cardiology, Department of Internal Medicine, Changhua Christian Hospital, 135 Nan-Shiao Street, Changhua, 500, Taiwan

    Ching-Pei Chen MD

  4. Department of Beauty Science, Graduate Institute of Beauty Science Technology, Changhua, Taiwan

    Ching-Pei Chen MD

  5. Department of Nuclear Medicine, Chang-Bing Show Chwan Memorial Hospital, 6 Lukon Road, Lukong Town, Changhua, 505, Taiwan

    Guang-Uei Hung MD

  6. Department of Medical Imaging and Radiological Science, Central Taiwan University of Science and Technology, Taichung, Taiwan

    Wen-Sheng Huang MD & Guang-Uei Hung MD

  7. Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan

    Guang-Uei Hung MD

  8. Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA

    Ji Chen PhD, FACC, FASNC

Authors
  1. Wen-Sheng Huang MD
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  2. Ching-Hui Huang MD
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  3. Cheng-Liang Lee MD
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  4. Ching-Pei Chen MD
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  5. Guang-Uei Hung MD
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  6. Ji Chen PhD, FACC, FASNC
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Corresponding authors

Correspondence to Ching-Pei Chen MD or Guang-Uei Hung MD.

Additional information

Wen-Sheng Huang and Ching-Hui Huang have contributed equally to this work.

See related editorial, doi:10.1007/s12350-014-9973-6.

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Huang, WS., Huang, CH., Lee, CL. et al. Relation of early post-stress left ventricular dyssynchrony and the extent of angiographic coronary artery disease. J. Nucl. Cardiol. 21, 1048–1056 (2014). https://doi.org/10.1007/s12350-014-9980-7

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  • DOI: https://doi.org/10.1007/s12350-014-9980-7

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