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HPV-16-associated lymphoepithelial-like carcinoma mimicking rectal tonsil

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Abstract

Lymphoepithelial-like carcinoma is a rare malignancy characterized by lack of cellular differentiation and associated nonneoplastic lymphoplasmacytic cell infiltrate that is rarely seen in the colon. Although many cases are associated with EBV infection, HPV may be present in LELC arising in sites known for HPV-driven malignancies, like the anogenital region. We report a case of lymphoepithelial-like carcinoma mimicking a rectal tonsil in a 51-year-old female. Attentive evaluation must be taken to identify this tumor in locations where prominent lymphoid stroma is an expected finding.

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References

  1. Wenig MB. Lymphoepithelial-like carcinomas of the head and neck. Semin Diagn Pathol. 2015;32(74–8):6.

    Google Scholar 

  2. Xue J, Yu H, Yan J, et al. Non-Epstein-Barr virus-associated double primary lymphoepithelioma-likecarcinoma of the esophagus and stomach: a case report andliterature review. Int J Clin Exp Med. 2015;8:10051–7.

    PubMed  PubMed Central  Google Scholar 

  3. Vilor M, Tsutsumi Y. Localization of Epstein-Barr virus genomein lymphoid cells in poorly differentiated adenocarcinoma with lymphoid stroma of the colon. Pathol Int. 1995;45:695–7.

    Article  CAS  Google Scholar 

  4. Palazzo J, Mittal RK. Lymphoepithelioma-like carcinoma of the rectum in a patient with ulcerative colitis. Am J Gastroenterol. 1996;91(2):398–9.

    CAS  PubMed  Google Scholar 

  5. Samaha S, Tawfik O, Horvat R, et al. Lymphoepithelioma-like carcinoma of the colon: report of a case with histologic, immunohistochemical, and molecular studies for Epstein-Barr virus. Dis Colon Rectum. 1998;41:925–8.

    Article  CAS  Google Scholar 

  6. De Petris G, Lev R, Quirk DM, et al. Lymphoepithelioma-like carcinoma of the colon in a patient with hereditary nonpolyposis colorectal can-cer. Arch Pathol Lab Med. 1999;123:720–4.

    Article  Google Scholar 

  7. Kon S, Kasai K, Tsuzuki N, et al. Lymphoepithelioma-like carcinoma of rectum: possible relationwith EBV. Pathol Res Pract. 2001;197:577–82.

    Article  CAS  Google Scholar 

  8. Kojima Y, Mogaki M, Takagawa R, et al. A case of lymphoepithelioma-like carcinoma of the colon with ulcerative colitis. J Gastroenterol. 2007;42:181–5.

    Article  Google Scholar 

  9. Delaney D, Chetty R. Lymphoepithelioma-like carci-noma of the colon. Int J Clin Exp Pathol. 2012;5:105–9.

    PubMed  PubMed Central  Google Scholar 

  10. Mori Y, Akagi K, Yano M, et al. Lymphoepithelioma-Like carcinoma of the colon. Case Rep Gastroenterol. 2013;7:127–33.

    Article  Google Scholar 

  11. Díaz C, Collazob F, Aceneroa J. Lymphoepithelioma-like carcinoma of the large intestine: a case report and literature review. Rev Esp Patol. 2018;51(1):18–22.

    Google Scholar 

  12. Quatrino G, Kampagianni O, Boudreaux CW, et al. Lymphoepithelial-like carcinoma involving a rectal tonsil. Clin Oncol. 2016;1:1078.

    Google Scholar 

  13. Farris A, Lauwers GY, Ferry JA, et al. The rectal tonsil a reactive lymphoid proliferation that may mimic lymphoma. Am J Surg Pathol. 2009;33:1075–9.

    Article  Google Scholar 

  14. Iezzoni JC, Gaffey MJ, Weiss LM. The role of Epstein-Barr virus in lymphoepithelioma-like carcinomas. Am J Clin Pathol. 1995;103:308–15.

    Article  CAS  Google Scholar 

  15. Scott K, Trainor J, McVeigh G et al. Int J Gynecol Pathol 38:183–188.

  16. NCCN guidelines for rectal cancer. National Comprehensive Cancer Network Website.

Download references

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Correspondence to Pallavi Kopparthy.

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All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Kopparthy, P., Chaffin, J., Feely, M.M. et al. HPV-16-associated lymphoepithelial-like carcinoma mimicking rectal tonsil. Clin J Gastroenterol 14, 810–814 (2021). https://doi.org/10.1007/s12328-021-01362-1

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  • DOI: https://doi.org/10.1007/s12328-021-01362-1

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