Rare case of adult intestinal hypoganglionosis and review of the literature


Intestinal hypoganglionosis is a rare condition in adults. We report a case of intestinal hypoganglionosis in the mid-distal transverse colon to splenic flexure in a 65-year-old female patient presenting with altered bowel habit and abdominal distension, and reviewed the current literature on this topic. Our patient had a medical history of neurofibromatosis type 1. A preoperative computed tomography (CT) scan demonstrated a grossly dilated transverse colon without obstruction. A laparotomy for subtotal colectomy was performed, with histopathology demonstrating intestinal hypoganglionosis.

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Correspondence to Thomas Surya Suhardja.

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Lee, A., Suhardja, T.S., Simpson, I. et al. Rare case of adult intestinal hypoganglionosis and review of the literature. Clin J Gastroenterol 14, 599–607 (2021). https://doi.org/10.1007/s12328-021-01342-5

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  • Hypoganglionosis
  • Intestinal hypoganglionosis
  • Intestinal innervation disorder
  • Colonic pseudo-obstruction