Family 1: a 39-year-old woman and her sister were admitted to our hospital for fundic gland polyps (FGPs). Their mother died of gastric cancer with FGPs. We performed repeated biopsies at close intervals, suspecting gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS). After a 1-year follow-up, the sisters were diagnosed with gastric cancer with FGP. We performed laparoscopic total gastrectomies with D1+lymph node dissection. Promoter 1B (exon 1B) of the APC gene (chr5: 112,043,224 T>C) contained a point mutation. The sisters were subsequently diagnosed with GAPPS as per the mutational analysis. Family 2 (unrelated to Family 1): a-24-year-old woman was referred for epigastralgia. EGD revealed FGPs localized in the proximal stomach. Pathological biopsy results showed severe dysplasia and adenocarcinoma in situ. Her father was simultaneously diagnosed with FGPs with GC localized in the proximal stomach. We performed laparoscopic total gastrectomies with D1+lymph node dissection. They had the same gene mutation as the family 1. Here, we report two Asian families with GAPPS successfully treated via laparoscopic total gastrectomy.
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Conflict of interest
Kosuke Kanemitsu, Hideo Baba, Masaaki Iwatsuki, Kohei Yamashita, Yoshihiro Komohara, Shiro Iwagami, Kojiro Eto, Takeshi Morinaga, Junji Kurashige, Yoshifumi Baba, Naoya Yoshida and Yohei Nagai declare that they have no conflict of interest.
All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.
All the procedures followed were in accordance with the ethical standards of the responsible committee and with the Helsinki Declaration. This study procedure was approved by the Institutional Review Board of Kumamoto University Hospital (No. 1037).
Written informed consent was obtained from all the patients.
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Kanemitsu, K., Iwatsuki, M., Yamashita, K. et al. Two Asian families with gastric adenocarcinoma and proximal polyposis of the stomach successfully treated via laparoscopic total gastrectomy. Clin J Gastroenterol 14, 92–97 (2021). https://doi.org/10.1007/s12328-020-01290-6
- Gastric cancer
- Gastric adenocarcinoma and proximal polyposis of the stomach
- Laparoscopic gastrectomy