Splenic artery pseudoaneurysm following chemotherapy in a patient with pancreatic cancer: a case report


A 48-year-old man presented with epigastralgia and back pain. Radiological evaluation revealed a pancreatic tail tumor with contrast enhancement and an intratumoral fluid component involving the splenic artery and invading the left kidney. Endoscopic ultrasound-guided fine-needle aspiration biopsy revealed an adenocarcinoma, and based on invasion of the left kidney, the patient was diagnosed with unresectable pancreatic cancer with suspected peritoneal dissemination. Radiological evaluation performed after the administration of eight courses of gemcitabine combined with nab-paclitaxel revealed stable disease without distant metastases or peritoneal dissemination. We planned to perform radical resection; however, the patient developed a pseudoaneurysm of the splenic artery preoperatively and initially underwent preoperative coil embolization, followed by radical resection (distal pancreatectomy with combined left nephrectomy and partial resection of the colon and stomach), 11 days after embolization. Histopathological examination of the resected specimen confirmed R0 resection, and the splenic artery pseudoaneurysm associated with pancreatic cancer was attributed to tumor invasion of this vessel. He showed satisfactory postoperative recovery and was discharged on the 24th day after surgery with administration of S-1 adjuvant chemotherapy.

This is a preview of subscription content, log in to check access.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6


  1. 1.

    Hackert T, Sachsenmaier M, Hinz U, et al. Locally advanced pancreatic cancer: neoadjuvant therapy with folfirinox results in resectability in 60% of the patients. Ann Surg. 2016;26:457–63.

    Article  Google Scholar 

  2. 2.

    Satoi S, Yamaue H, Kato K, et al. Role of adjuvant surgery for patients with initially unresectable pancreatic cancer with a long-term favorable response to non-surgical anti-cancer treatments: results of a project study for pancreatic surgery by the Japanese Society of Hepato-Biliary-Pancreatic Surgery. J Hepatobiliary Pancreat Sci. 2013;20:590–600.

    Article  Google Scholar 

  3. 3.

    Heinrich S, Lang H. Neoadjuvant therapy of pancreatic cancer: definitions and benefits. Int J Mol Sci. 2017;18:E1622.

    Article  Google Scholar 

  4. 4.

    Pasha SF, Gloviczki P, Stanson AW, et al. Splanchnic artery aneurysms. Mayo Clin Proc. 2007;82:472–9.

    Article  Google Scholar 

  5. 5.

    Sachdev-Ost U. Visceral artery aneurysms: review of current management options. Mt Sinai J Med. 2010;77:296–303.

    Article  Google Scholar 

  6. 6.

    Nanez L, Knowles M, Modrall JG, et al. Ruptured splenic artery aneurysms are exceedingly rare in pregnant women. J Vasc Surg. 2014;60:1520–3.

    Article  Google Scholar 

  7. 7.

    White AF, Baum S, Buranasiri S. Aneurysms secondary to pancreatitis. AJR Am J Roentgenol. 1976;127:393–6.

    CAS  Article  Google Scholar 

  8. 8.

    Furukawa H, Fukushima N, Shimada K. Splenic artery aneurysm secondary to pancreatic carcinoma. Am J Gastroenterol. 2000;95:3659–60.

    CAS  Article  Google Scholar 

  9. 9.

    Toukouki A, Verbeeck N, Weber J, et al. Intragastric rupture of a splenic artery aneurysm associated with a pancreatic cancer. J Belg Soc Radiol. 2016;100:26.

    Article  Google Scholar 

  10. 10.

    Hoshimoto S, Aiura K, Shito M, et al. Successful resolution of a hemorrhagic pancreatic pseudocyst ruptured into the stomach complicating obstructive pancreatitis due to pancreatic cancer: a case report. World J Surg Oncol. 2016;14:46.

    Article  Google Scholar 

  11. 11.

    Miao YD, Ye B. Intragastric rupture of splenic artery aneurysms: Three case reports and literature review. Pak J Med Sci. 2013;29:656–9.

    PubMed  PubMed Central  Google Scholar 

  12. 12.

    Loffroy R, Guiu B, Cercueil JP, et al. Transcatheter arterial embolization of splenic artery aneurysms and pseudoaneurysms: short- and long-term results. Ann Vasc Surg. 2008;22:618–26.

    Article  Google Scholar 

Download references

Author information




KF: collection of data and drafting of the article. HS: revision of the article. YS: collection of data. YN: collection of data. MS: collection of data. KY: revision of the article and final approval of the article.

Corresponding author

Correspondence to Kenei Furukawa.

Ethics declarations

Conflict of interest

The authors have no conflicts of interest to declare.

Human/animal rights

This study was approved by the Ethics Committee of the Jikei University School of Medicine.

Informed consent

This patient provided informed consent.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Furukawa, K., Shiba, H., Shirai, Y. et al. Splenic artery pseudoaneurysm following chemotherapy in a patient with pancreatic cancer: a case report. Clin J Gastroenterol (2020). https://doi.org/10.1007/s12328-020-01137-0

Download citation


  • Splenic artery pseudoaneurysm
  • Chemotherapy
  • Pancreatic cancer