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Gastric adenocarcinoma coexisting with a reddish semipedunculated polyp arising from Helicobacter pylori-negative normal gastric mucosa: a report of two cases

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Abstract

We experienced two cases of adenocarcinoma coexisting with a hyperplastic polyp arising from Helicobacter pylori-negative normal gastric mucosa. The first case was of a 59-year-old man. Esophagogastroduodenoscopy revealed a protruding lesion measuring 4 mm in diameter on the greater curvature of the middle gastric body. The second case was of a 47-year-old man. Esophagogastroduodenoscopy showed a protruding lesion measuring 5 mm located at the greater curvature of the upper gastric body. The absence of atrophic changes in the entire gastric mucosa was confirmed endoscopically in both cases. Multiple H. pylori tests were all negative. Endoscopically, these protruding lesions appeared as reddish, semipedunculated polyps. Hyperplastic polyps were suspected based on white light endoscopic findings. Magnified endoscopy with narrow band imaging could not predict the coexistence of cancer. However, histopathological examination of the resected specimen revealed focal cancer at the surface of the gastric hyperplastic polyps. Considering the possibility that cancer may be coexisting in polyps, when reddish polyps are detected in H. pylori-negative normal gastric mucosa, it is important to perform a biopsy, or a careful follow-up endoscopy.

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Authors and Affiliations

  1. Department of Gastroenterology, Suzuka General Hospital, 1275-53 Yamanohana, Yasuzuka, Suzuka, Mie, Japan

    Yoshiaki Isono, Katsumi Mukai, Hiroki Asakawa, Kenji Nose, Satomi Tsuruga, Tomomasa Tochio, Hiroaki Kumazawa, Hiroki Tanaka, Shimpei Matsusaki, Tomohiro Sase, Tomonori Saito & Hiroshi Okano

  2. Department of Pathology, Suzuka General Hospital, 1275-53 Yamanohana, Yasuzuka, Suzuka, Mie, Japan

    Youichirou Baba

  3. Happy GI Clinic, 2-9-33 Honmachi, Kameyama, Mie, Japan

    Hideki Toyoda

Authors
  1. Yoshiaki Isono
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  2. Youichirou Baba
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  3. Katsumi Mukai
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  4. Hiroki Asakawa
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  5. Kenji Nose
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  6. Satomi Tsuruga
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  7. Tomomasa Tochio
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  8. Hiroaki Kumazawa
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  9. Hiroki Tanaka
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  10. Shimpei Matsusaki
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  11. Tomohiro Sase
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  12. Tomonori Saito
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  13. Hiroshi Okano
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  14. Hideki Toyoda
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Corresponding author

Correspondence to Yoshiaki Isono.

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The authors declare that they have no conflict of interest.

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All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 of Declaration of Helsinki and its later amendments.

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Informed consent was obtained from all patients being included in the study.

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Isono, Y., Baba, Y., Mukai, K. et al. Gastric adenocarcinoma coexisting with a reddish semipedunculated polyp arising from Helicobacter pylori-negative normal gastric mucosa: a report of two cases. Clin J Gastroenterol 11, 481–486 (2018). https://doi.org/10.1007/s12328-018-0887-8

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  • DOI: https://doi.org/10.1007/s12328-018-0887-8

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