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Granular cell tumor of the pancreas diagnosed by endoscopic ultrasound-guided fine-needle aspiration

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Abstract

A 68-year-old woman was referred to our hospital for the treatment of bile duct stone, pancreatic tumor, and pancreatic cysts. First, bile duct stone was removed using endoscopic retrograde cholangiopancreatography. By abdominal contrast-enhanced computed tomography, a 12-mm diameter tumor was found in the pancreatic body. The tumor was isodense compared with the surrounding pancreatic parenchyma in the non-contrast phase and poorly enhanced in the arterial phase; it exhibited gradual enhancement from the portal vein phase to the late phase. Numerous pancreatic cysts were also observed by contrast-enhanced computed tomography. By magnetic resonance imaging, the tumor was hypointense in T1-weighted images, isointense in T2-weighted images, and hyperintense in diffusion-weighted images. By magnetic resonance cholangiopancreatography, the main pancreatic duct was not dilated, and pancreatic cysts communicated with the main pancreatic duct. The pancreatic cysts were diagnosed as branch-type intraductal papillary mucinous neoplasm. Histopathologic assessment of the specimens obtained by endoscopic ultrasound-guided fine-needle aspiration revealed the tumor as benign pancreatic granular cell tumor. The patient was followed up without surgical resection. On contrast-enhanced computed tomography at 6 months after admission, the tumor did not show any changes in diameter or characteristics.

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Acknowledgements

The authors would like to thank all the staff involved in diagnosis and treatment of pancreatobiliary disease at Chiba University Hospital.

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Authors and Affiliations

  1. Department of Gastroenterology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan

    Koji Takahashi, Rintaro Mikata, Toshio Tsuyuguchi, Junichiro Kumagai, Masato Nakamura, Yotaro Iino, Ayako Shingyoji, Mutsumi Yamato, Hiroshi Ohyama, Yuko Kusakabe, Shin Yasui, Harutoshi Sugiyama & Naoya Kato

  2. Department of Molecular Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan

    Takashi Kishimoto

  3. Department of Diagnostic Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan

    Yukio Nakatani

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  1. Koji Takahashi
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  2. Rintaro Mikata
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  3. Toshio Tsuyuguchi
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  4. Junichiro Kumagai
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  8. Mutsumi Yamato
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  11. Shin Yasui
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  12. Harutoshi Sugiyama
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  13. Takashi Kishimoto
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  14. Yukio Nakatani
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  15. Naoya Kato
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Corresponding author

Correspondence to Koji Takahashi.

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Conflict of interest

Koji Takahashi, Rintaro Mikata, Toshio Tsuyuguchi, Junichiro Kumagai, Masato Nakamura, Yotaro Iino, Ayako Shingyoji, Mutsumi Yamato, Hiroshi Ohyama, Yuko Kusakabe, Shin Yasui, Harutoshi Sugiyama, Takashi Kishimoto, Yukio Nakatani, and Naoya Kato declare that they have no conflict of interest.

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This study does not include any data about human specimen. All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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This is a case report and does not involve human subjects and does not apply to giving informed consent.

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Takahashi, K., Mikata, R., Tsuyuguchi, T. et al. Granular cell tumor of the pancreas diagnosed by endoscopic ultrasound-guided fine-needle aspiration. Clin J Gastroenterol 11, 193–199 (2018). https://doi.org/10.1007/s12328-018-0821-0

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  • DOI: https://doi.org/10.1007/s12328-018-0821-0

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