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A case of Crohn’s disease associated with Takayasu’s arteritis and Henoch-Schönlein purpura

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Abstract

A 14-year-old Japanese man was diagnosed with Crohn’s disease in October 2001. Four years later, the patient was referred to our institution because of neck pain, fever and asymmetrical blood pressure. Magnetic resonance angiography, computed tomography and ultrasonography revealed findings compatible with Takayasu’s arteritis. In March 2006, the patient developed purpura over bilateral hands and lower extremities, arthralgia, lower abdominal pain and microhematuria. The patient was diagnosed with Henoch-Schönlein purpura. This is the first reported case of Crohn’s disease associated with two types of vascular complications.

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References

  1. Yassinger S, Adelman R, Cantor D, Halsted CH, Bolt RJ. Association of inflammatory bowel disease and large vascular lesions. Gastroenterology. 1976;71:258–63.

    Google Scholar 

  2. Reny JL, Paul JF, Lefebvre C, Champion K, Emmerich J, Bletry O, et al. Association of Takayasu’s arteritis and Crohn’s disease. Results of a study on 44 Takayasu patients and review of the literature. Ann Med Interne. 2003;154:85–90.

    Google Scholar 

  3. Baqir M, Usman MH, Adenwalla HN, Aziz S, Noor F, ul-Islam T, et al. Takayasu’s arteritis with skin manifestations in a patient with inflammatory bowel disease: coincidence or concurrence? Clin Rheumatol. 2007;26:996–8.

    Article  PubMed  Google Scholar 

  4. Bernstein CN, Blanchard JF. The epidemiology of Crohn’s disease. Gastroenterology. 1999;116:1503–4.

    Article  CAS  PubMed  Google Scholar 

  5. Kerr GS, Hallahan CW, Giordano J, Leavitt RY, Fauci AS, Rottem M, et al. Takayasu arteritis. Ann Intern Med. 1994;120:919–29.

    Article  CAS  PubMed  Google Scholar 

  6. Masu T, Haga T, Okuyama R, Aiba S. A case of anaphylactoid purpura associated with exacerbation of Crohn’s disease (in Japanese with English abstract). Nishi Nihon Hifuka. 2005;67:201–3.

    Article  Google Scholar 

  7. Saulsbury FT, Hart MH. Crohn’s disease presenting with Henoch–Schönlein purpura. J Pediatr Gastroenterol Nutr. 2000;31:173–5.

    Article  CAS  PubMed  Google Scholar 

  8. Kuhn C, Stepniowska-Kienig T, Prusek W, Suszek J. Coexistence of Lesniowski-Crohn disease and Schonlein-Henoch syndrome. Pediatr Pol. 1974;49:483–5.

    CAS  PubMed  Google Scholar 

  9. Annese V, Piepoli A, Latiano A, Lombardi G, Napolitano G, Caruso N, et al. HLA-DRB1 alleles may influence disease phenotype in patients with inflammatory bowel disease: a critical reappraisal with review of the literature. Dis Colon Rectum. 2005;48:57–64.

    Article  CAS  PubMed  Google Scholar 

  10. Salazar M, Varela A, Ramirez LA, Uribe O, Vasquez G, Egea E, et al. Association of HLA-DRB1*1602 and DRB1*1001 with Takayasu arteritis in Colombian mestizos as markers of Amerindian ancestry. Int J Cardiol. 2000;75:S113–6.

    Article  PubMed  Google Scholar 

  11. Saruhan-Direskeneli G, Bicakcigil M, Yilmaz V, Kamali S, Aksu K, Fresko I, et al. Interleukin (IL)-12, IL-2, and IL-6 gene polymorphisms in Takayasu’s arteritis from Turkey. Hum Immunol. 2006;67:735–40.

    Article  CAS  PubMed  Google Scholar 

  12. Wada Y, Lu R, Zhou D, Chu J, Przewloka T, Zhang S, et al. Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL-23 inhibitor. Blood. 2007;109:1156–64.

    Article  CAS  PubMed  Google Scholar 

  13. Tanaka F, Kawakami A, Iwanaga N, Tamai M, Yasumori I, Aratake K, et al. Infliximab is effective for Takayasu arteritis refractory to glucocorticoid and methotrexate. Intern Med. 2006;45:313–6.

    Article  PubMed  Google Scholar 

  14. Imasawa T, Utsunomiya Y, Kawamura T, Nagasawa R, Maruyama N, Sakai O. Evidence suggesting the involvement of hematopoietic stem cell in the pathogenesis of IgA nephropathy. Biochem Biophys Res Commun. 1998;249:605–11.

    Article  CAS  PubMed  Google Scholar 

  15. Shaer AJ, Stewart LR, Cheek DE, Hurray D, Self SE. IgA antiglomerular basement membrane nephritis associated with Crohn’s disease: a case report and review of glomerulonephritis in inflammatory bowel disease. Am J Kidney Dis. 2003;41:1097–9.

    Article  PubMed  Google Scholar 

  16. Cassater D, Gambaro G, Fabris A, Cena C, Calabria S, Capelluto S, et al. Henoch–Schönlein purpura and Crohn’s disease in a family. J Nephrol. 2006;19:387–90.

    CAS  PubMed  Google Scholar 

  17. Savage CO, Harper L, Cockwell P, Adu D, Howie AJ. ABC of arterial and vascular disease: vasculitis. BMJ. 2000;320:1325–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Kawasaki Y, Hosoya M, Suzuki H. Possible pathologenic role of interleukin-5 and eosino cationic protein in Henoch–Schönlein purpura nephritis. Pediatr Int. 2005;47:512–7.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Kotaro Ogawa, Takayuki Matsumoto, Shinichiro Yada, Atsushi Hirano, Yoshiteru Kumagae, Kenichi Goto & Mitsuo Iida

  2. Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Kazunori Urabe

Authors
  1. Kotaro Ogawa
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  2. Takayuki Matsumoto
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  3. Shinichiro Yada
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  4. Atsushi Hirano
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  5. Yoshiteru Kumagae
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  6. Kenichi Goto
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  7. Kazunori Urabe
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  8. Mitsuo Iida
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Correspondence to Kotaro Ogawa.

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Ogawa, K., Matsumoto, T., Yada, S. et al. A case of Crohn’s disease associated with Takayasu’s arteritis and Henoch-Schönlein purpura. Clin J Gastroenterol 2, 166–169 (2009). https://doi.org/10.1007/s12328-009-0062-3

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  • DOI: https://doi.org/10.1007/s12328-009-0062-3

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