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Hereditary hemorrhagic telangiectasia with multiple hepatic and pulmonary nodular lesions

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Abstract

A 50-year-old female visited the hospital for further evaluation of multiple pulmonary and hepatic nodules. First, she visited her primary physician for general fatigue due to anemia. She had recurrent epistaxis, and her mother had suffered from hereditary hemorrhagic telangiectasia (HHT). Telangiectasias were present in the stomach. This patient was diagnosed with HHT. Computed tomography (CT) revealed multiple pulmonary and hepatic nodules. The pulmonary nodules were due to bleeding from arteriovenous malformations of the lung. Abdominal CT and angiography showed a dilated and meandering hepatic artery, arteriovenous shunts and multiple hepatic nodules. Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) showed enhancement in the early dynamic phase and in the liver-specific phase. A liver tumor biopsy of a hepatic nodule showed nodular regenerative hyperplasia (NRH). This report presents a case of HHT with multiple pulmonary and hepatic nodular lesions. Gd-EOB-DTPA-enhanced MRI was useful for making a diagnosis of NRH.

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Authors and Affiliations

  1. Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3-39-15 Showa-Machi, Maebashi, Gunma, 371-8511, Japan

    Yasuyuki Shimoyama, Satoru Kakizaki, Akiko Katano, Satoshi Takakusaki, Masafumi Mizuide, Takeshi Ichikawa, Ken Sato, Hitoshi Takagi & Masatomo Mori

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  1. Yasuyuki Shimoyama
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  2. Satoru Kakizaki
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  3. Akiko Katano
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  4. Satoshi Takakusaki
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  5. Masafumi Mizuide
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  6. Takeshi Ichikawa
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  7. Ken Sato
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  8. Hitoshi Takagi
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  9. Masatomo Mori
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Correspondence to Satoru Kakizaki.

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Shimoyama, Y., Kakizaki, S., Katano, A. et al. Hereditary hemorrhagic telangiectasia with multiple hepatic and pulmonary nodular lesions. Clin J Gastroenterol 2, 131–136 (2009). https://doi.org/10.1007/s12328-008-0054-8

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  • DOI: https://doi.org/10.1007/s12328-008-0054-8

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