Efficacy of Endovenous Laser Treatment Combined with Sclerosing Foam in Treating Varicose Veins of the Lower Extremities



This study aims to investigate the efficacy of incision-free endovenous laser treatment (EVLT) combined with sclerosing foam in treating varicose veins of the lower extremities.


A total of 140 patients (186 limbs) who underwent laser closure of the great saphenous vein + injection sclerotherapy were included in the present study. Preoperative information, intraoperative conditions, duration of the operation, and length of hospital stay were recorded in detail. During the 6-month follow-up, the closure of the trunk and branches of the great saphenous vein, postoperative pain, the recovery of ulcer and dermatitis, and postoperative complications were traced.


All patients were treated with laser closure of the great saphenous vein and lauromacrogol injection. Twenty-six stage C6 limbs (lower extremity with ulcer) healed within 6 months, and the postoperative subjective pain disappeared after 1 month. In six patients, pigmentation in the surgical site did not completely disappear at 6 months after the operation. Saphenous nerve injury was found in five patients within 3 months after the operation, and all healed at 6 months after the operation.


EVLT combined with sclerosing foam is effective for treating varicose great saphenous veins.

Trial Registration

This study was registered at http://www.chictr.org.cn (registration number: ChiCTR1900021409).

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We thank the participants of the study.


No funding or sponsorship was received for this study or publication of this article. The article processing charges were funded by the authors.


All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.


Zhao-Xuan Liu, Pei-Ming Guo, Ling-Ling Zhang, Meng-Jie Shi, Rui-Hua Wang and Qing-Yi Meng have nothing to disclose.

Compliance with Ethics Guidelines

This study was conducted in accordance with the 1964 declaration of Helsinki and its later amendments and was approved by the Ethics Committee of Affiliated Ji’nan Central Hospital of Shandong University. Written informed consent was obtained from all participants.

Data Availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Corresponding author

Correspondence to Qing-Yi Meng.

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Liu, ZX., Guo, PM., Zhang, LL. et al. Efficacy of Endovenous Laser Treatment Combined with Sclerosing Foam in Treating Varicose Veins of the Lower Extremities. Adv Ther 36, 2463–2474 (2019). https://doi.org/10.1007/s12325-019-01011-7

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  • Complication
  • Endovenous laser
  • Foam sclerotherapy
  • Surgery
  • Varicose veins of lower extremity (VVLE)