Advances in Therapy

, Volume 34, Issue 10, pp 2181–2198 | Cite as

The Impact of Histologic Phenotype in the Treatment of Sinonasal Cancer

  • Fernando López
  • Valerie J. Lund
  • Carlos Suárez
  • Carl H. Snyderman
  • Nabil F. Saba
  • K. Thomas Robbins
  • Vincent Vander Poorten
  • Primož Strojan
  • William M. Mendenhall
  • Alessandra Rinaldo
  • Alfio Ferlito


The management of sinonasal cancer is a challenge due to its low occurrence and anatomical and significant diversity of histological types. The therapeutic modality used should be tailored individually according to the histology, tumour stage, molecular profile and previous treatments. The clinical management of sinonasal cancer has improved greatly owing to developments in endoscopic surgery and precision radiotherapy. Complete surgical resection is the mainstay of sinonasal malignancies' management but multimodality therapy is associated with improved outcomes in certain histologies. The recognition of various histological types with biological behaviours more suitable for non-surgical modalities has allowed treatment protocols to become more tailored to the disease. In this review we aim to describe and to summarise the current data guiding the management of sinonasal cancer with emphasis on phenotypic variation.


Endoscopic surgery Histology Oncology Paranasal cavities Radiotherapy Sinonasal cancer 



No funding or sponsorship was received for this study or publication of this article. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this manuscript, take responsibility for the integrity of the work as a whole and have given final approval for the version to be published. This article was written by members of the International Head and Neck Scientific Group (


Fernando López, Valerie J. Lund, Carlos Suárez, Carl H. Snyderman, Nabil F. Saba, K. Thomas Robbins, Vincent Vander Poorten, Primož Strojan, William M. Mendenhall, Alessandra Rinaldo and Alfio Ferlito have nothing to disclose.

Compliance with Ethics Guidelines

This article is based on previously conducted studies and does not involve any new studies of human or animal subjects performed by any of the authors.


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Copyright information

© Springer Healthcare Ltd. 2017

Authors and Affiliations

  • Fernando López
    • 1
    • 2
  • Valerie J. Lund
    • 3
  • Carlos Suárez
    • 2
  • Carl H. Snyderman
    • 4
  • Nabil F. Saba
    • 5
  • K. Thomas Robbins
    • 6
  • Vincent Vander Poorten
    • 7
  • Primož Strojan
    • 8
  • William M. Mendenhall
    • 9
  • Alessandra Rinaldo
    • 10
  • Alfio Ferlito
    • 11
  1. 1.Department of OtolaryngologyHospital Universitario Central de AsturiasOviedoSpain
  2. 2.Instituto Universitario de Oncología del Principado de Asturias, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias and CIBERONC, ISCIIIOviedoSpain
  3. 3.Professorial Unit, Ear InstituteUniversity College LondonLondonUK
  4. 4.Department of OtolaryngologyUniversity of Pittsburgh School of MedicinePittsburghUSA
  5. 5.Department of Hematology and Medical OncologyThe Winship Cancer Institute of Emory UniversityAtlantaUSA
  6. 6.Division of Otolaryngology-Head and Neck SurgerySouthern Illinois University School of MedicineSpringfieldUSA
  7. 7.Otorhinolaryngology-Head and Neck Surgery and Department of Oncology, Section Head and Neck Oncology, University Hospitals LeuvenKU LeuvenLeuvenBelgium
  8. 8.Department of Radiation OncologyInstitute of OncologyLjubljanaSlovenia
  9. 9.Department of Radiation OncologyUniversity of Florida College of MedicineGainesvilleUSA
  10. 10.University of Udine School of MedicineUdineItaly
  11. 11.Coordinator of the International Head and Neck Scientific GroupPaduaItaly

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