Table 3 Cerebellum and brainstem MRI biometry (cm) in participants divided by age (< or ≥ 36 months)

From: Clinical and radiological correlates of activities of daily living in cerebellar atrophy caused by PMM2 mutations (PMM2-CDG)

  Patients (n: 23) Controls (n: 19) p Value Patients < 36 mos. (n: 9) Controls < 36 mos. (n: 8) p Value Patients ≥ 36 mos. (n: 14) Controls ≥ 36 mos. (n: 11) p Value
Age (years), mean (SD) 7.9 (6.8) 6.2 (5.4) 0.375 1.5 (1) 1.3 (1) 0.173 11.1 (4.5) 10 (3.8) 0.448
MCD 7.67 (1.0) 9.25 (1.09) < 0.001a 6.92 (0.85) 8.14 (0.84) 0.026a 7.93 (0.94) 9.90 (0.56) 0.001a
CCD 2.34 (0.79) 4.18 (0.45) < 0.001a 2.13 (0.25) 3.76 (0.41) < 0.001a 2.42 (0.90) 4.43 (0.26) 0.001a
TVA 18.7 (6.61) 9.99 (3.36) < 0.001a 14.8 (3.20) 10.2 (5.2) 0.076 20.1 (6.60) 9.88 (3.58) 0.001a
Mesencephalon 1.01 (0.23) 1.02 (0.15) 0.885 0.89 (0.10) 0.90 (0.12) 0.876 1.05 (0.25) 1.08 (0.11) 0.670
Mid-pons 1.64 (0.29) 1.92 (0.24) 0.001a 1.53 (0.20) 1.69 (0.16) 0.159 1.68 (0.31) 2.06 (0.17) 0.001a
Medulla 1.03 (0.19) 1.10 (0.18) 0.196 0.96 (0.13) 0.90 (0.10) 0.646 1.05 (0.20) 1.17 (0.18) 0.127
Clava 1.09 (0.10) 1.15 (0.15) 0.103 1.04 (0.03) 1.01 (0.09) 0.394 1.10 (0.11) 1.24 (0.11) 0.005a
  1. Age age at MRI, MCD maximum transverse cerebellar diameter, CCD maximum craniocaudal cerebellar diameter, TVA tegmento-vermian angle. aStatistically significant