Clinical and radiological correlates of activities of daily living in cerebellar atrophy caused by PMM2 mutations (PMM2-CDG)

Table 3 Cerebellum and brainstem MRI biometry (cm) in participants divided by age (< or ≥ 36 months)

	Patients (n: 23)	Controls (n: 19)	p Value	Patients < 36 mos. (n: 9)	Controls < 36 mos. (n: 8)	p Value	Patients ≥ 36 mos. (n: 14)	Controls ≥ 36 mos. (n: 11)	p Value
Age (years), mean (SD)	7.9 (6.8)	6.2 (5.4)	0.375	1.5 (1)	1.3 (1)	0.173	11.1 (4.5)	10 (3.8)	0.448
MCD	7.67 (1.0)	9.25 (1.09)	< 0.001^a	6.92 (0.85)	8.14 (0.84)	0.026^a	7.93 (0.94)	9.90 (0.56)	0.001^a
CCD	2.34 (0.79)	4.18 (0.45)	< 0.001^a	2.13 (0.25)	3.76 (0.41)	< 0.001^a	2.42 (0.90)	4.43 (0.26)	0.001^a
TVA	18.7 (6.61)	9.99 (3.36)	< 0.001^a	14.8 (3.20)	10.2 (5.2)	0.076	20.1 (6.60)	9.88 (3.58)	0.001^a
Mesencephalon	1.01 (0.23)	1.02 (0.15)	0.885	0.89 (0.10)	0.90 (0.12)	0.876	1.05 (0.25)	1.08 (0.11)	0.670
Mid-pons	1.64 (0.29)	1.92 (0.24)	0.001^a	1.53 (0.20)	1.69 (0.16)	0.159	1.68 (0.31)	2.06 (0.17)	0.001^a
Medulla	1.03 (0.19)	1.10 (0.18)	0.196	0.96 (0.13)	0.90 (0.10)	0.646	1.05 (0.20)	1.17 (0.18)	0.127
Clava	1.09 (0.10)	1.15 (0.15)	0.103	1.04 (0.03)	1.01 (0.09)	0.394	1.10 (0.11)	1.24 (0.11)	0.005^a

Age age at MRI, MCD maximum transverse cerebellar diameter, CCD maximum craniocaudal cerebellar diameter, TVA tegmento-vermian angle. ^aStatistically significant