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Socioeconomic Status and the Cerebellar Grey Matter Volume. Data from a Well-Characterised Population Sample

Abstract

The cerebellum is highly sensitive to adverse environmental factors throughout the life span. Socioeconomic deprivation has been associated with greater inflammatory and cardiometabolic risk, and poor neurocognitive function. Given the increasing awareness of the association between early-life adversities on cerebellar structure, we aimed to explore the relationship between early life (ESES) and current socioeconomic status (CSES) and cerebellar volume. T1-weighted MRI was used to create models of cerebellar grey matter volumes in 42 adult neurologically healthy males selected from the Psychological, Social and Biological Determinants of Ill Health study. The relationship between potential risk factors, including ESES, CSES and cerebellar grey matter volumes were examined using multiple regression techniques. We also examined if greater multisystem physiological risk index—derived from inflammatory and cardiometabolic risk markers—mediated the relationship between socioeconomic status (SES) and cerebellar grey matter volume. Both ESES and CSES explained the greatest variance in cerebellar grey matter volume, with age and alcohol use as a covariate in the model. Low CSES explained additional significant variance to low ESES on grey matter decrease. The multisystem physiological risk index mediated the relationship between both early life and current SES and grey matter volume in cerebellum. In a randomly selected sample of neurologically healthy males, poorer socioeconomic status was associated with a smaller cerebellar volume. Early and current socioeconomic status and the multisystem physiological risk index also apparently influence cerebellar volume. These findings provide data on the relationship between socioeconomic deprivation and a brain region highly sensitive to environmental factors.

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Funding

We thank Dr Mortimer and Theresa Sackler Foundation for their support. This work was funded by the Glasgow Centre for Population Health, a partnership between NHS Greater Glasgow and Clyde, Glasgow City Council and the University of Glasgow, supported by the Scottish Government. The Glasgow Centre for Population Health had a role in study design, data collection and analysis, decision to publish and the preparation of the manuscript.

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Correspondence to Jonathan Cavanagh.

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Cavanagh, J., Krishnadas, R., Batty, G.D. et al. Socioeconomic Status and the Cerebellar Grey Matter Volume. Data from a Well-Characterised Population Sample. Cerebellum 12, 882–891 (2013). https://doi.org/10.1007/s12311-013-0497-4

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Keywords

  • Cerebellum
  • Socioeconomic status
  • Deprivation
  • Cognition