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Peripheral Blood Cell Interactions of Cancer-Derived Exosomes Affect Immune Function

  • Heather R. Ferguson Bennit
  • Amber Gonda
  • James R. W. McMullen
  • Janviere Kabagwira
  • Nathan R. Wall
Original Article

Abstract

Cancer-derived exosomes are constitutively produced and secreted into the blood and biofluids of their host patients providing a liquid biopsy for early detection and diagnosis. Given their ubiquitous nature, cancer exosomes influence biological mechanisms that are beneficial to the tumor cells where they are produced and the microenvironment in which these tumors exist. Accumulating evidence suggests that exosomes transport proteins, lipids, DNA, mRNA, miRNA and long non coding RNA (lncRNA) for the purpose of cell-cell and cell-extracellular communication. These exosomes consistently reflect the status as well as identity of their cell of origin and as such may conceivably be affecting the ability of a functional immune system to recognize and eliminate cancer cells. Recognizing and mapping the pathways in which immune suppression is garnered through these tumor derived exosome (TEX) may lead to treatment strategies in which specific cell membrane proteins or receptors may be targeted, allowing for immune surveillance to once again help with the treatment of cancer. This Review focuses on how cancer exosomes interact with immune cells in the blood.

Keywords

Exosome Non-Hodgkin’s lymphoma B cell 

Notes

Funding

Research reported in this publication was supported by NIH awards P20MD006988.

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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Heather R. Ferguson Bennit
    • 1
    • 2
  • Amber Gonda
    • 1
    • 3
  • James R. W. McMullen
    • 1
    • 2
  • Janviere Kabagwira
    • 1
    • 2
  • Nathan R. Wall
    • 1
    • 2
    • 4
  1. 1.Center for Health Disparities & Molecular MedicineLoma Linda University School of MedicineLoma LindaUSA
  2. 2.Department Basic Science and Division of BiochemistryLoma Linda University School of MedicineLoma LindaUSA
  3. 3.Department of AnatomyLoma Linda University School of MedicineLoma LindaUSA
  4. 4.Center for Health Disparities Research & Molecular MedicineLoma Linda UniversityLoma LindaUSA

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