Andrographolide: Regulating the Master Regulator NF-κB

Abstract

Natural product based medicines are being used in India since 12th century BC and their efficacies are well established in Indian traditional medicine system. However, the mechanism of action as per the modern medicinal system was not well reported. Plant-derived natural compounds are very useful for inflammatory disorders and other diseases such as cancer. Various medicines like artemisinin, vincristine, vinblastine, taxol, and so forth, are invaluable contributions of nature to modern medicine. The role of transcription factor NF-κB was well delineated in inflammatory processes. Binding of NF-κB to the promoter site of several inflammatory genes activate them to secrete proinflammatory cytokines and chemokines. Plant derived natural compounds like andrographolide could be useful in inflammatory disorders as it directly inhibit the binding of NF-κB with DNA at promoter site. Transcription factor NF-κB is a master regulator of the proinflammatory gene expression program and since it was suppressed by andrographolide, hence andrographolide is rightly termed as regulator of master regulator.

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References

  1. 1.

    Mishra KP, Sharma N, Soree P, Gupta RK, Ganju L, Singh SB. Hypoxia-induced inflammatory chemokines in subjects with a history of high-altitude pulmonary edema. Indian J Clin Biochem. 2016;31(1):81–6.

    CAS  Article  Google Scholar 

  2. 2.

    Kumar R, Jain V, Kushwah N, Dheer A, Mishra KP, Prasad D, Singh SB. Role of DNA methylation in hypobaric hypoxia-induced neurodegeneration and spatial memory impairment. Ann Neurosci. 2018;25(4):191–200.

    Article  Google Scholar 

  3. 3.

    Khanna K, Mishra KP, Chanda S, Eslavath MR, Ganju L, Kumar B, Singh SB. Effects of Acute Exposure to hypobaric hypoxia on mucosal barrier injury and the gastrointestinal immune axis in rats. High Alt Med Biol. 2019;20(1):35–44.

    CAS  Article  Google Scholar 

  4. 4.

    Das S, Mishra KP, Ganju L, Singh SB. Andrographolide—a promising therapeutic agent, negatively regulates glial cell derived neurodegeneration of prefrontal cortex, hippocampus and working memory impairment. J Neuroimmunol. 2017;15(313):161–75.

    Article  Google Scholar 

  5. 5.

    Gupta S, Mishra KP, Dash PK, Parida M, Ganju L, Singh SB. Andrographolide inhibits chikungunya virus infection by up-regulating host innate immune pathways. Asian Pac J Trop Med. 2018;11:214–21.

    CAS  Article  Google Scholar 

  6. 6.

    Gupta S, Mishra KP, Ganju L. Broad-spectrum antiviral properties of andrographolide. Arch Virol. 2017;162(3):611–23.

    CAS  Article  Google Scholar 

  7. 7.

    Gupta S, Mishra KP, Singh SB, Ganju L. Inhibitory effects of andrographolide on activated macrophages and adjuvant-induced arthritis. Inflammopharmacology. 2018;26(2):447–56.

    CAS  Article  Google Scholar 

  8. 8.

    Mishra KP, Ganju L, Singh SB. Hypoxia modulates innate immune factors: a review. Int Immunopharmacol. 2015;28(1):425–8.

    CAS  Article  Google Scholar 

  9. 9.

    Xia YF, Ye BQ, Li YD, Wang JG, He XJ, Lin X, Yao X, Ma D, Slungaard A, Hebbel RP, Key NS. Andrographolide attenuates inflammation by inhibition of NF-κB activation through covalent modification of reduced cysteine 62 of p50. J Immunol. 2004;173(6):4207–17.

    CAS  Article  Google Scholar 

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Acknowledgements

This work was financially supported by DRDO, Ministry of Defence, Govt. of India in the form of NBC subproject.

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Correspondence to KP Mishra.

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Mishra, K. Andrographolide: Regulating the Master Regulator NF-κB. Ind J Clin Biochem 36, 117–119 (2021). https://doi.org/10.1007/s12291-019-00866-5

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Keywords

  • Inflammation
  • Andrographolide
  • Cytokines
  • Chemokines
  • Natural products