Vanillic Acid in Endometrial Carcinoma: A Role for Nitric Oxide?
- 34 Downloads
To the Editor
The recent article by Bhavani et al. , reported that vanillic acid (VA) should prevent the effect of the carcinogen N-methyl-N′-nitro-N-nitroso-guanidine (MNNG) on the induction of endometrial carcinoma in Albino female Wistar rats. The study showed that pre-treatment of animals with 100 mg/kg b.w of vanillic acid before the intra-vaginal introduction of 150 mg/0.2 ml olive oil (750 mg/ml) of MNNG, reduced by 70% the tumor incidence . This reduction has to be most probably attributed to the effect of VA, as the protocol in which VA and MNNG were up-taken together by rats in the same experimental setting, did not succeed in reducing tumor incidence with the same extent . The paper by Bhavani et al. , showed that VA fundamentally affected the plasma level of some markers of the oxidative stress response, i.e. reducing LOOH and SOD (lipid hydro-peroxides and superoxide dismutase) and much more moderately affecting CYP450 (increase), CAT, GPx and GSH (decrease)....
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no conflict of interest.
- 3.Sivaperumal R, Subash S, Subramanian P. Influences of aspartate on circadian patterns of lipid peroxidation products and antioxidants in Wistar rats. Singap Med J. 2007;48(11):1033–8.Google Scholar