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Indian Journal of Clinical Biochemistry

, Volume 33, Issue 2, pp 190–195 | Cite as

Effects of Alternanthera sessilis on Liver Function in Carbon Tetra Chloride Induced Hepatotoxicity in Wister Rat Model

  • Biman Bhuyan
  • Krishna Baishya
  • Prakash Rajak
Original Article
  • 60 Downloads

Abstract

Alternanthera sessilis commonly known as ‘sessile joy weed’ or ‘dwarf copperleaf’ is found throughout the hotter parts of India up to an altitude of 1200 m2. In Assam, the plant has been traditionally used in the treatment of jaundice along with other ailments. The study focuses primarily on the evaluation of hepatoprotective activity of the plant with special references to its putative protective role in carbon tetrachloride induced liver injury on Wister albino rat. The in vivo hepatoprotective activity of the methanolic extract at the dose of 250 mg/kg body weight was highly effective in controlling SGPT, SGOT, ALP, serum cholesterol and serum bilirubin level as compared to silymarin. The said extract also significantly lowered the lipid profile caused by CCl4. The activity shown by methanolic extract of the whole plant of A. sessilis is of considered importance and thus justified its use in controlling hepatic diseases in traditional treatment system.

Keywords

Alternanthera sessilis Methanolic extract Hepatoprotective Lipid profile 

Notes

Acknowledgement

This study was not funded by any sort of grant or others whatsoever.

Compliance with Ethical Standards

Conflict of interest

All authors declare that they have no conflict of interests.

Human and Animal Rights

All procedures performed in studies involving animals were in accordance with the ethical standards promulgated by the Institutional Animal Care Committee, CPCSEA, India. The institutional registration number is 1576/GO/a/11/CPCSE dated: 17/2/2012. The present study is approved vide Approval No. IACE/DU/64 Dated 24/9/2013.

References

  1. 1.
    Agarwal A. Current issues in quality control of natural products. Pharma Times. 2005;37(6):9–11.Google Scholar
  2. 2.
    Chatterjee I, Chakravarty AK, Gomesa A. Current and future status of herbal medicines. Br J Ethnopharmacol. 2006;106(1):38–43.CrossRefPubMedGoogle Scholar
  3. 3.
    Kashaw V. Hepatportective prospective of herbal drugs and their vesicular carriers—a review. Inter J Res Pharm Biomed Sci. 2011;2(2):360–74.Google Scholar
  4. 4.
    Adailkan PG, Gauthaman K. History of herbal medicines with an insight on the pharmacological properties of Tribulus terrestris. Aging Male. 2001;4:163–9.CrossRefGoogle Scholar
  5. 5.
    Cooke DW, Plotnick L. Type I diabetes mellitus in pediatrics. J Ethnopharm. 2008;29:374–85.Google Scholar
  6. 6.
    Handa SS, Sharma A, Chakraborti P. Natural products and plants as liver protecting drugs. Fitoterapia. 1986;57:307–49.Google Scholar
  7. 7.
    Sharma A, Singh RT, Sehgal V, Handa SS. Antihepatotoxic activity of some plants used in herbal formulations. Fitoterapia. 1991;62:113–21.Google Scholar
  8. 8.
    Rajiv G, Singh HK. Nootropic potential of Alternanthera sessilis and Clerodendrum infortunatum leaves on mice. Asian Pac J Trop Dis. 2012;2(1):465–70.Google Scholar
  9. 9.
    Hosamani KM, Ganjihal SS, Chavadi DV. Alternanthera triandra seed oil: a moderate source of ricinoleic acid and its possible industrial utilization. Indian Crop Prod. 2004;19:133–6.CrossRefGoogle Scholar
  10. 10.
    Acharya E, Pokherl B. Ethno-medicinal plants used by Bantar of Bhaudaha Morang, Nepal. Nat. 2006;4:96–103.Google Scholar
  11. 11.
    Rekha R. Hepatoprotective activity of Mimosa pudica leaves against carbon tetrachloride induced toxicity. J Nat Prod. 2009;2:116–22.Google Scholar
  12. 12.
    Okhawa H, Oishi N, Yagi K. Assay for lipid peroxides in animal tissue by thiobarbituric acid reaction. Anal Biochem. 1979;95:351–8.CrossRefGoogle Scholar
  13. 13.
    Mulder TPJ, Manni JJ, Roelofs HMJ, Peters WHM, Wiersma A. Glutathione-S-transferases and glutathione in human head and neck cancer. Carcinogenesis. 1995;16:619–24.CrossRefPubMedGoogle Scholar
  14. 14.
    Bergmeyer HU, Gawehn K. Methods of enzymatic analysis. 2nd ed. New York: Academic Press; 1963. p. 886–8.Google Scholar
  15. 15.
    Noor A, Gunasekaran S, Soosaimanickam A, Vijayalakshmi MA. Antidiabetic activity of Aloe vera and histology of organs in streptozotocin induced diabetic rats. Curr Sci. 2008;94:1070–6.Google Scholar
  16. 16.
    Aruna RV, Ramesh B, Kartha VN. Effect of betacarotene on protein glycosylation in alloxan induced diabetic rats. Indian J Exp Bio. 1999;37:399–401.Google Scholar

Copyright information

© Association of Clinical Biochemists of India 2017

Authors and Affiliations

  1. 1.Department of Pharmaceutical SciencesDibrugarh UniversityDibrugarhIndia

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