Indian Journal of Clinical Biochemistry

, Volume 33, Issue 2, pp 214–217 | Cite as

Homeostatic Model Assessment-Insulin Resistance (HOMA-IR 2) in Mild Subclinical Hypothyroid Subjects

  • Shreejita Sengupta
  • T. Jaseem
  • Jayachidambaram Ambalavanan
  • Anupama Hegde
Original Article


Despite various studies with conflicting results, the effect of thyroid hormones on lipids and insulin levels in dysthyroidism is of great interest. This case control study was aimed to perceive the existence of IR and dyslipidemia in mild subclinical hypothyroid subjects (TSH ≤ 9.9 µIU/ml) as compared to their age and gender matched euthyroid controls. Basic demographic information like height, weight was recorded. Serum samples of all the subjects were assayed for thyroid profile, lipid profile, blood glucose, HbA1C and insulin. BMI and insulin resistance was calculated. Compared to controls patients with mild subclinical hypothyroidism demonstrated hyperinsulinemia and dyslipidemia observed by the higher LDL cholesterol. A significantly positive correlation was observed for HOMA-IR with TSH and LDL cholesterol. Hence, even in the mild subclinical hypothyroid state assessment of thyroid function should be combined with estimation of plasma glucose, insulin and serum lipids to monitor and prevent its associated effects.


Dyslipidemia HOMA-IR-2 Insulin resistance Subclinical hypothyroidism 



The authors thank all the patients and hospital staffs for their co-operation during the study. The study is partially funded by Manipal University.

Compliance with Ethical Standards

Conflict of interest

Authors declare that they have no conflict of interest.


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Copyright information

© Association of Clinical Biochemists of India 2017

Authors and Affiliations

  • Shreejita Sengupta
    • 1
  • T. Jaseem
    • 2
  • Jayachidambaram Ambalavanan
    • 1
  • Anupama Hegde
    • 2
  1. 1.Kasturba Medical CollegeManipal UniversityMangaluruIndia
  2. 2.Department of Biochemistry, Center for Basic Sciences, Kasturba Medical CollegeManipal UniversityMangaluruIndia

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