Non-Hodgkin lymphoma (NHL) is an etiologically, clinically, and histologically heterogeneous group of lymphoproliferative disorders. Immune dysfunction is a well-known risk factor and dysregulation of cytokines may mediate disease progression. Obesity is one of the important relations connecting immune system abnormalities and lymphomagenesis. We conducted a study to find out the association between obesity as measured by body mass index (BMI), and risk of non-Hodgkin lymphoma (NHL) development by assessment the of inflammatory cytokines levels, (IL-6, IL-10, IFN-gamma and CRP) and adipokines levels (leptin and adiponectin). Also, to predict the effect of higher BMI on the incidence of NHL. The study included 180 NHL patients and 172 healthy controls. The inflammatory markers (IL-6, IL-10, IFN-γ & CRP) together with adiponectin were assessed by ELISA technique. IL-6, IL-10, CRP, IFN-γ and Adiponectin were statistically higher in cases than control. A positive significant difference of Leptin (p-value 0.001) was found with higher levels in patients with BMI (≥ 25 kg/m2) than in patients with < 25 kg/m2. IL-6, IL-10, CRP, IFN-γ and Adiponectin could be implicated in lymphomagenesis in Egyptian NHL. The study results support the hypothesis that obesity has a major role in the development of NHL. An association between Leptin and NHL risk with higher levels in patients with BMI (≥ 25 kg/m2) was proved.
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The work described has not been published previously except in the form of an abstract accepted in the EHA; Inflammation & Adiposity Circulatory Markers In B-Non Hodgkin Lymphoma (B-NHL): An Egyptian Single Center Study: HemaSphere: June 2019—Volume 3—Issue—pp. 933–934. https://doi.org/10.1097/01.HS9.0000566768.18417.3e. Patient number was 45 and 43 healthy controls in the abstract, we increased the number in the original study to 172 patients and 180 healthy control.
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El Demerdash, D.M., Tawfik, N.M., Elazab, R. et al. The Association of Pre-diagnostic Inflammatory Markers and Adipokines and the Risk of Non-Hodgkin Lymphoma Development in Egypt. Indian J Hematol Blood Transfus (2020). https://doi.org/10.1007/s12288-020-01305-9
- Inflammatory markers