Tacrolimus Induced Diabetic Ketoacidosis Following Hematopoietic Stem Cell Transplantation

Abstract

Risk of diabetes mellitus increases after solid organ and hematopoietic stem cell transplantation. Diabetic ketoacidosis has been reported after solid organ transplantation in patients receiving tacrolimus but has rarely been reported after stem cell transplantation. The major risk factors for diabetic ketoacidosis are immunosuppressive drugs used after transplantation. We report here three cases of allogenic stem cell transplant who developed diabetic ketoacidosis while on treatment with tacrolimus. The drug was stopped in all the cases and patients were treated with insulin therapy resulting in complete recovery from diabetic ketoacidosis.

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Acknowledgements

We are thankful to Ms Bharti for collecting the data.

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Correspondence to Sanjeev Kumar Sharma.

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Sharma, S.K., Doval, D., Khandelwal, V. et al. Tacrolimus Induced Diabetic Ketoacidosis Following Hematopoietic Stem Cell Transplantation. Indian J Hematol Blood Transfus 35, 711–713 (2019). https://doi.org/10.1007/s12288-019-01113-w

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Keywords

  • Tacrolimus
  • Stem cell transplant
  • Diabetic ketoacidosis