Abstract
Worldwide, there is a rise in the incidence of dengue infection associated with multiple serotypes. Epidemiological studies have reported a higher incidence of severe dengue in secondary dengue infections. A rapid fall in platelet count associated with an increase in hematocrit above the baseline is one of the warning signs of plasma leakage. This study was undertaken to determine the utility of platelet indices such as mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit in dengue fever cases with thrombocytopenia. A hospital-based cross-sectional study was carried out between April and September 2014, among dengue patients with thrombocytopenia using platelet histograms. The study population included all the laboratory confirmed cases of dengue infection with thrombocytopenia admitted at Kasturba Medical College, Manipal, Karnataka during the study period. The blood samples collected from serologically confirmed dengue patients with thrombocytopenia were analyzed using automated analyzer within 2 h of venipuncture. The platelet histograms (MPV, PDW, Plateletcrit) generated by the Beckman Coulter counter LH755™ and LH780™ series were assessed in dengue fever cases with thrombocytopenia. The mean platelet volume (MPV) was observed to be 9.01 fL (SD = 0.09). The mean platelet distribution width and median plateletcrit were 17.2% (SD = 0.98) and 0.47 (IQR 0.2–0.8) respectively. None of the study participants presented with bleeding manifestations. The present study revealed no significant changes of platelet parameters in dengue cases with thrombocytopenia.
Similar content being viewed by others
References
NVBDCP National Vector Borne Disease Control Programme. [cited 2017 Jul 14]. http://www.nvbdcp.gov.in/den-cd.html
Guabiraba R, Ryffel B (2014) Dengue virus infection: current concepts in immune mechanisms and lessons from murine models. Immunology 141:143–156
Martina BEE, Koraka P, Osterhaus ADME (2009) Dengue virus pathogenesis: an integrated view. Clin Microbiol Rev 22:564–581
Chuansumrit A, Tangnararatchakit K (2006) Pathophysiology and management of dengue hemorrhagic fever. Transfus Altern Transfus Med 8:3–11
Jayashree K, Manasa GC, Pallavi P, Manjunath GV (2011) Evaluation of platelets as predictive parameters in dengue Fever. Indian J Hematol Blood Transfus 27:127–130
Chatterjee N, Mukhopadhyay M, Ghosh S, Mondol M, Das C, Patar K (2014) An observational study of dengue fever in a tertiary care hospital of eastern India. J Assoc Physicians India 62:224–227
Jackson SR, Carter JM (1993) Platelet volume: laboratory measurement and clinical application. Blood Rev 7:104–113
Wiwanitkit V (2004) Mean platelet volume in the patients with dengue hemorrhagic fever. Platelets 15:185
Sharma K, Yadav A (2015) Association of mean platelet volume with severity, serology and treatment outcome in dengue fever: prognostic utility. J Clin Diagn Res 9:EC01–EC03
Bashir AB, Saeed OK, Mohammed BA, Ageep AK (2015) Role of platelet indices in patients with dengue infection in Red Sea State, Sudan. Int J Sci Res 4:1573–1576
Nehara HR, Meena SL, Parmar S, Gupta BK (2016) Evaluation of platelet indices in patients with dengue infections. Int J Sci Res 5(7). https://worldwidejournals.in/ojs/index.php/ijsr/article/view/10379
Acknowledgements
We acknowledge our sincere gratitude to the study participants.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors of this manuscript have no conflicts of interest, including specific financial interests, relationships, and/or affiliations relevant to the subject matter or materials included.
Rights and permissions
About this article
Cite this article
Khatri, S., Sabeena, S., Arunkumar, G. et al. Utility of Platelet Parameters in Serologically Proven Dengue Cases with Thrombocytopenia. Indian J Hematol Blood Transfus 34, 703–706 (2018). https://doi.org/10.1007/s12288-018-0924-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12288-018-0924-2