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Invasive Fungal Infections in Acute Promyelocytic Leukemia on Dual Differentiating Agents: Real World Data

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Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

Invasive fungal infection (IFI) in patients with acute promyelocytic leukemia (APL) is a common phenomenon in developing countries. In a systematic study (Dual Inducing Differentiating agents—Indian Trial: DID-IT) using dual differentiating agents (ATO and ATRA) in 98 APL patients at our center we report 18.3% incidence of IFI (n-18). Among all cases of IFI three were definitive, 14 were probable and one was possible IFI. We conclude that incidence of IFI in APL is affected by environmental and therapy related factors and mere usage of dual differentiating agents need not necessarily decrease the incidence of fungal infections.

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Authors’ Contributions

All authors participated in the study, YU, PKK and PM analyzed the data and wrote the paper, SV and PM designed the research study and AC’s laboratory performed fungal studies. All authors were involved in the management of the patients. YU and PM were involved in the manuscript preparation. All authors vetted the submitted manuscript.

Funding

This study was not funded by any agency.

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Authors and Affiliations

  1. Department of Haematology and Stem Cell Transplant, Army Hospital (Research and Referral), Delhi, 110010, India

    Uday Yanamandra

  2. Department of Internal Medicine and Clinical Hematology, P.G.I.M.E.R, Chandigarh, U.T, 160012, India

    Parathan Karunakaran, Alka Khadwal, Gaurav Prakash, Deepesh Lad, Subhash Varma & Pankaj Malhotra

  3. Department of Hematopathology, P.G.I.M.E.R, Chandigarh, U.T, 160012, India

    Shano Naseem & Neelam Varma

  4. Department of Medical Microbiology, P.G.I.M.E.R, Chandigarh, U.T, 160012, India

    Arunaloke Chakrabarti

Authors
  1. Uday Yanamandra
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  2. Parathan Karunakaran
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  3. Alka Khadwal
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  4. Gaurav Prakash
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  5. Deepesh Lad
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  6. Shano Naseem
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  7. Neelam Varma
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  8. Arunaloke Chakrabarti
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  9. Subhash Varma
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  10. Pankaj Malhotra
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Corresponding author

Correspondence to Pankaj Malhotra.

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Conflict of interest

All authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

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Yanamandra, U., Karunakaran, P., Khadwal, A. et al. Invasive Fungal Infections in Acute Promyelocytic Leukemia on Dual Differentiating Agents: Real World Data. Indian J Hematol Blood Transfus 34, 466–468 (2018). https://doi.org/10.1007/s12288-017-0894-9

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  • DOI: https://doi.org/10.1007/s12288-017-0894-9

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