Incidental Discovery of Anti-IH in a Patient Planned for Caesarean Section and it’s Repercussions

  • Lin-Nan Shao
  • Wen-Qian Song
  • Ni Wang
  • Wei-Jian Yu
  • Shi-Hang Zhou
A 27-year-old pregnant woman, 37 weeks pregnant, tested positive during antibody screening at Maternity and Child Healthcare Hospital. She had one child born by caesarian operation and no history of transfusions. She was referred to our blood center to reserve blood for caesarean operation. The blood groups of her and her husband are listed in Table  1. At room temperature (RT), forward grouping was A 1B group with D positive. Reverse grouping results were negative for A cells, weak agglutination (w +) for B cells and 2 + agglutination for O cells. Autocontrol and direct antiglobulin (IgG + C3d) test were both negative. Antibody screening results of the commercially available panel (Sanquin, Makropanal 16, Lot: 8000236600) are showed in Table  1. Further investigation revealed that by immediate spin, the antibody was strongly reactive against A 2RBCs but not against O and B cord RBCs, suggesting that it is anti-IH. In order to identify whether the plasma contains other specific...


Anti-IH Compound antibody Pan-agglutination Pregnant woman 


Compliance with Ethical Standards

Conflict of interest

There is no conflict of interest to declare.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.


  1. 1.
    Ibanez C, Habibi A, Mekontso-Dessap A, Chadebech P, Chami B, Bierling P et al (2016) Anti-HI can cause a severe delayed hemolytic transfusion reaction with hyperhemolysis in sickle cell disease patients. Transfusion 56:1828–1833CrossRefPubMedGoogle Scholar
  2. 2.
    Boonyasampant M, Weitz IC, Kay B, Boonchalermvichian C, Liebman HA, Shulman IA (2015) Life-threatening delayed hyperhemolytic transfusion reaction in a patient with sickle cell disease: effective treatment with eculizumab followed by rituximab. Transfusion 55:2398–2403CrossRefPubMedGoogle Scholar
  3. 3.
    Irani MS, Richards C (2011) Hemolytic transfusion reaction due to anti-IH. Transfusion 51:2676–2678CrossRefPubMedGoogle Scholar
  4. 4.
    Darabi K, Makar RS (2008) Acute hemolysis of transfused A2 red cells by an auto-HI antibody. Transfusion 48:964–968CrossRefPubMedGoogle Scholar
  5. 5.
    Campbell SA, Shirey RS, King KE, Ness PM (2000) An acute hemolytic transfusion reaction due to anti-IH in a patient with sickle cell disease. Transfusion 40:828–831CrossRefPubMedGoogle Scholar

Copyright information

© Indian Society of Hematology and Blood Transfusion 2017

Authors and Affiliations

  1. 1.Dalian Blood CenterDalianChina

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