Myeloperoxidase Deficient Acute Promyelocytic Leukemia: Report of Two Cases
Acute promyelocytic leukemia (APL) is characterized by the presence of ‘abnormal promyelocytes’ which show variable morphology but a characteristic strong myeloperoxidase (MPO) positivity on cytochemistry and immunohistochemistry (IHC). The characteristic morphology and cytochemistry is often considered as a strong evidence to make a morphological diagnosis of APL and often enough to prompt a haematologist to start all-trans-retinoic acid (ATRA), before a confirmatory molecular diagnosis arrives. We herein describe two cases of classical APL having an absent/reduced MPO activity.
Compliance with Ethical Standards
Conflict of interest
All authors declare that they do not have any conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors. The article does not include any identifying information of any individual.
- 4.Borregaard N, Boxer LA (2016) Disorders of neutrophil function. In: Lichtman MA, Kipps TJ, Seligsohn U, Kaushansky K, Prchal JT (eds) Williams hematology, 9e. McGraw-Hill, New YorkGoogle Scholar