Abstract
We report analysis of all consecutive Hodgkins disease patients undergoing autologous hematopoietic stem cell transplant from September 1999 to December 2014. Out of total 38 patients 26 were males and 12 were females. 32 were adults and 6 were pediatric (<18 years). None were elderly. Median age was 28 years (9–61). All received BEAM protocol as conditioning regimen. Median engraftment time for granulocytes was 12 and 14 days for platelets. Thirty three (86.84 %) patients achieved complete remission out of which 8 (24.24 %) had further relapse. Transplant related mortality occurred in 4 (10 %) patients. Finally 26 (78.78 %) patients were disease free at median follow up of 60 months and median disease free survival (DFS) was 35 months. DFS was 66.66 and 65 %, respectively on 3 and 5 years. While overall survival was 70.83 and 70 % on 3 and 5 years, respectively.
Similar content being viewed by others
References
Diehl V, Franklin J, Pfreundschuh M et al (2003) Standard and increased chemotherapy compared with COPP–ABVD for advanced Hodgkin’s disease. N Engl J Med 348:2386–2395
Longo D, Duffey P, Young R et al (1992) Conventional-dose salvage combination chemotherapy in patients relapsing with Hodgkin’s disease after combination chemotherapy: the low probability for cure. J Clin Oncol 10:210–218
Ljungman P, Bregni M, Brune M et al (2010) Allogenic and autologous transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe 2009. Bone Marrow Transpl 45:219–234
Armitage JO (2010) Early-stage Hodgkin’s lymphoma. N Engl J Med 363(7):653–662
Kuruvilla J (2009) Standard therapy of advanced Hodgkin lymphoma. Hematol Am Soc Hematol Educ Program 2009:497–506
Sureda A, Schouten HC (2012) HSCT for Hodgkin’s lymphoma in adults. In: Apperley J, Carreras E, Gluckman E, Masszi T (eds) Hematopoietic stem cell transplantation, 6th edn. Forum service editore, Paris, p 431
Linch DC, Winfield D, Goldstone AH et al (1993) Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin’s disease: results of a BNLI randomised trial. Lancet 341(8852):1051–1054
Schmitz N, Pfistner B, Sextro M et al (2002) Aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous hematopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin’s disease: a randomised trial. Lancet 359(9323):2065–2071
Josting A, Muller H, Borchmann P et al (2010) Dose intensity of chemotherapy in patients with relapsed Hodgkin’s lymphoma. J Clin Oncol 28:5074–5080
Kumar L, Ganessan P, Ghosh I, Panda D, Gogia A, Mandhania S (2010) Autologous blood stem cell transplantation for Hodgkin and non-Hodgkin lymphoma: complications and outcome. Natl Med J India 23(6):330–335
Chopra R, Macmillan AK, Linch DC et al (1993) The place of high-dose BEAM therapy and autologous bone marrow transplantation in poor risk Hodgkin’s disease: a single center eight year study of 155 patients. Blood 81:1137–1145
Sweetenham JW, Carella AM, Taghipour G et al (1999) High dose therapy and autologous stem cell transplantation for adult patients with Hodgkin’s disease who fail to enter remission after induction chemotherapy: results in 175 patients reported to the EBMT. J Clin Oncol 17:3101–3109
Rapoport AP, Rowe JM, Dipersio JF (1991) High-dose chemotherapy followed by autologous stem cell rescue for refractory Hodgkin’s disease and non-Hodgkin’s lymphoma. In: Zander AR, Barlogie B (eds) Autologous bone marrow transplantation for Hodgkin’s diseases, non-Hodgkin’s lymphoma and multiple myeloma. Springer-Verlag, Berlin. http://www.science-connections.com/trends/human_leukemia/109.htm.htm
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Raut, S., Shah, S., Shah, K. et al. Improving Outcome of Hodgkins Disease with Autologous Hematopoietic Stem Cell Transplantation. Indian J Hematol Blood Transfus 32, 176–181 (2016). https://doi.org/10.1007/s12288-015-0559-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12288-015-0559-5