Abstract
Acute lymphoblastic leukemia presenting with bone involvement and multiple osteolytic lesions has been commonly reported in pediatric population. Various myeloid and lymphoid malignancies can rarely present with bony lesions. We are reporting an adult female patient with acute lymphoblastic leukemia who presented with paraparesis and multiple osteolytic lesions in skull initially giving false impression of multiple myeloma.
References
Muler JH, Valdez R, Hayes C et al (2002) Acute megakaryocytic leukemia presenting as hypercalcemia with skeletal lytic lesions. Eur J Haematol 68:392–396
Kwong YL, Ng I, Leung S (1990) Osteolytic skeletal lesions in chronic myeloid leukemia. Pathology 22:123–125
Kubota K, Yanagisawa T, Kurabayashi H et al (1989) Hypercalcemia associated with osteolytic lesions in the extramedullary blast crisis of chronic myelogenous leukemia: report of a case. Blut 59:458–459
Rossi J, Bataille R, Chappard D et al (1987) B cell malignancies presenting with unusual bone involvement and mimicking multiple myeloma. Am J Med 83:10–16
Stein A, Boughton BJ (1988) Common acute lymphoblastic leukaemia in an adult with hypercalcemia and lytic bone lesions. Br J Haematol 70:503
Shimonodan H, Nagayama J, Nagatoshi Y (2005) Acute lymphocytic leukemia in adolescence with multiple osteolytic lesions and hypercalcemia mediated by lymphoblast-producing parathyroid hormone-related peptide: a case report and review of the literature. Pediatr Blood Cancer 45(6):333–339
Abbas A, Husain AH, Abdelaal A et al (2001) Acute lymphoblastic leukemia presenting with extensive skeletal lesions and bone marrow necrosis. Med Pediatr Oncol 37:64–66
Buyukavci M, Karacan M, Olgun H, Tan H (2003) Significance of bone marrow examination in the diagnostic process of paraspinal mass in children: a case report. J Pediatr Hematol Oncol 25(10):822–823
Ch’ien LT, Kalwinsky DK, Peterson G et al (1982) Metastatic epidural tumors in children. Med Pediatr Oncol 10:455–462
Pui C-H, Dahl GV, Hustu HO, Murphy SB (1985) Epidural spinal cord compression as the initial finding in childhood acute leukemia and non Hodgkin lymphoma. J Pediatr 106:788–792
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Verma, S.P., Dubashi, B., Basu, D. et al. A Rare Case of Adult Acute Lymphoblastic Leukemia Presenting with Paraparesis and Multiple Osteolytic Lesions. Indian J Hematol Blood Transfus 30 (Suppl 1), 24–26 (2014). https://doi.org/10.1007/s12288-012-0221-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12288-012-0221-4