Zusammenfassung
Epuliden sind fokale reaktive Hyperplasien der Gingiva. Nach ihrer Histologie werden das teleangiektatische Granulom (Epulis granulomatosa), die fokale fibröse Hyperplasie (Epulis fibromatosa), das periphere ossifizierende Fibrom (ossifizierende fibroide Epulis) und das periphere Riesenzellgranulom (Riesenzellepulis) unterschieden. Epuliden gehen vom periodontalen Ligament aus und entwickeln sich aus dem Sulcus gingivalis, infiltrieren aber den darunterliegenden Knochen nicht. Als Therapie genügt eine konservative Abtragung, auch wenn Rezidive nicht selten vorkommen können (bis zu 17,5 % beim peripheren Riesenzellgranulom). Da eine eindeutige klinische Diagnose nicht möglich ist und zahlreiche gutartige, aber auch maligne Tumoren differenzialdiagnostisch in Betracht kommen, sollten die Läsionen immer histologisch untersucht werden.
Abstract
The term epulis denotes a focal reactive hyperplasia of the gingiva. Histologically, epulides are devided into telangiectatic granuloma (epulis granulomatosa), focal fibrous hyperplasia (epulis fibromatosa), peripheral ossifying fibroma (fibroid ossifying epulis), and peripheral giant cell granuloma (giant cell epulis). Epulides originate from the periodontal ligament and develop from the gingival sulcus; however, there is no infiltration of the underlying bone. They are treated sufficiently by conservative local excision, although recurrences may develop (with peripheral giant cell granuloma in up to 17.5% of cases). Since the lesions cannot be diagnosed purely on clinical grounds, and benign as well as malignant tumors have to be considered in the differential diagnosis, histological examination must be performed.
Literatur
Agrawal AA (2015) Gingival enlargements: differential diagnosis and review of literature. World J Clin Cases 3:779–788. https://doi.org/10.12998/wjcc.v3.i9.779
Allon I, Pessing A, Kaplan I et al (2014) Metastatic tumors to the gingiva and the presence of teeth as a contributing factor: a literature analysis. J Periodontol 85:132–139. https://doi.org/10.1902/jop.2013.130118
Bhaskar SN, Jacoway JR (1966) Peripheral fibroma and peripheral fibroma with calcification: report of 376 cases. J Am Dent Assoc 73:1312–1320
Bodner L, Peist M, Gatot A et al (1997) Growth potential of peripheral giant cell granuloma. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol 83:548–551. https://doi.org/10.1016/S1079-2104(97)90118-9
Brooks JK, Nikitakis NG, Goodman NJ et al (2002) Clinicopathologic characterization of oral angioleiomyomas. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol 94:221–227. https://doi.org/10.1067/moe.2002.125276
Buchner A, Merrell PW, Hansen LS et al (1990) The retrocuspid papilla of the mandibular lingual gingiva. J Periodontol 61:585–589. https://doi.org/10.1902/jop.1990.61.9.585
Buchner A, Shnaiderman-Shapiro A, Vered M (2010) Relative frequency of localized reactive hyperplastic lesions of the gingiva: a retrospective study of 1675 cases from Israel. J Oral Pathol Med 39:631–638. https://doi.org/10.1111/j.1600-0714.2010.00895.x
Choi C, Terzian E, Schneider R et al (2008) Peripheral giant cell granuloma associated with hyperparathyroidism secondary to end-stage renal disease: a case report. J Oral Maxillofac Surg 66:1063–1066. https://doi.org/10.1016/j.joms.2007.11.030
Daley TD, Nartey NO, Wysocki GP (1991) Pregnancy tumor: an analysis. Oral Surg Oral Med Oral Pathol 72:196–199
Darling M, Thompson I, Schneider J (2002) Spindle cell lipoma of the alveolar mucosa: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol 93:171–173. https://doi.org/10.1067/moe.2002.120520
Eversole LR (2009) Cellular angiofibroma of oral mucosa: report of two cases. Head Neck Pathol 3(01):136–139. https://doi.org/10.1007/s12105-009-0112-7
Eversole LR, Rovin S (1972) Reactive lesions of the gingiva. J Oral Pathol 1:30–38
Fanburg-Smith JC, Furlong MA, Childers EL (2003) Oral and salivary gland angiosarcoma: a clinicopathologic study of 29 cases. Mod Pathol 16:263–271. https://doi.org/10.1097/01.mp.0000056986.08999.fd
Goldblum JR, Folpe AL, Weiss SW (2014) Enzinger and Weiss’s soft tissue tumors. 6th ed. Elsevier-Saunders, Philadelphia
Groesser L, Peterhof E, Evert M et al (2016) BRAF and RAS Mutations in Sporadic and Secondary Pyogenic Granuloma. J Investig Dermatol 136:481–486. https://doi.org/10.1038/JID.2015.376
Hagström J, Mesimäki K, Apajalahti S et al (2011) A rare case of oral epithelioid sarcoma of the gingiva. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol 111:e25–e28. https://doi.org/10.1016/j.tripleo.2010.12.014
Hopp RN, De Siqueira DC, Sena-Filho M et al (2013) Oral vascular malformation in a patient with hereditary hemorrhagic telangiectasia: a case report. Spec Care Dentist 33:150–153. https://doi.org/10.1111/j.1754-4505.2011.00218.x
Ide F, Shimoyama T, Horie N et al (2004) Comparative ultrastructural and immunohistochemical study of perineurioma and neurofibroma of the oral mucosa. Oral Oncol 40:948–953. https://doi.org/10.1016/j.oraloncology.2004.04.015
Joshi S, Mazumdar S, Pandit MK (2015) Peripheral ossifying fibroma on edentulous mandibular alveolar mucosa. J Maxillofac Oral Surg 14:84–86. https://doi.org/10.1007/s12663-011-0323-9
Kalpidis CD, Lysitsa SN, Lombardi T et al (2006) Gingival involvement in a case series of patients with acquired immunodeficiency syndrome-related Kaposi sarcoma. J Periodontol 77:523–533. https://doi.org/10.1902/jop.2006.050226
Kanda N, Watanabe S (2005) Regulatory roles of sex hormones in cutaneous biology and immunology. J Dermatol Sci 38:1–7. https://doi.org/10.1016/j.jdermsci.2004.10.011
Kfir Y, Buchner A, Hansen LS (1980) Reactive lesions of the gingiva. A clinicopathological study of 741 cases. J Periodontol 51:655–661. https://doi.org/10.1902/jop.1980.51.11.655
Koutlas IG, Scheithauer BW (2010) Palisaded encapsulated (“solitary circumscribed”) neuroma of the oral cavity: a review of 55 cases. Head Neck Pathol 4(01):15–26. https://doi.org/10.1007/s12105-010-0162-x
Lee KW (1968) The fibrous epulis and related lesions. Periodontics 6:277–292
Lester SR, Cordell KG, Rosebush MS et al (2014) Peripheral giant cell granulomas: a series of 279 cases. Oral Surg Oral Med Oral Pathol Oral Radiol 118:475–482. https://doi.org/10.1016/j.oooo.2014.06.004
Lewis JS (2008) Spindle cell lesions-neoplastic or non-neoplastic? Head Neck Pathol 2:103–110. https://doi.org/10.1007/s12105-008-0055-4
Lim YH, Douglas SR, Ko CJ et al (2015) Somatic activating RAS mutations cause vascular tumors including pyogenic granuloma. J Investig Dermatol 135:1698–1700. https://doi.org/10.1038/jid.2015.55
Magnusson BC, Rasmusson LG (1995) The giant cell fibroma. A review of 103 cases with immunohistochemical findings. Acta Odontol Scand 53:293–296
Montebugnoli L, Venturi M, Gissi DB et al (2010) Low-grade myofibroblastic sarcoma of the gingiva. BMJ Case Rep. https://doi.org/10.1136/bcr.07.2010.3166
Naqvi J, Ordonez NG, Luna MA et al (2008) Epithelioid Hemangioendothelioma of the head and neck: role of podoplanin in the differential diagnosis. Head Neck Pathol 2:25–30. https://doi.org/10.1007/s12105-007-0035-0
Owosho AA, Xu B, Kadempour A et al (2016) Metastatic solid tumors to the jaw and oral soft tissue: A retrospective clinical analysis of 44 patients from a single institution. J Craniomaxillofac Surg 44:1047–1053. https://doi.org/10.1016/j.jcms.2016.05.013
Pontes FS, Conte Neto N, Da Costa RM et al (2014) Periodontal growth in areas of vascular malformation in patients with Sturge-Weber syndrome: a management protocol. J Craniofac Surg 25:e1–e3. https://doi.org/10.1097/SCS.0b013e3182a2eb1d
Prisse LA, Jayasooriya PR, Mendis BR et al (2015) Benign fibrous histiocytomas of the oral mucosa: report on three cases and review of the literature. Dermatopathology 2:52–60. https://doi.org/10.1159/000381618
Rao GV, Sravya T, Sivaranjani Y et al (2014) Primary biphasic synovial sarcoma of gingiva: report of a rare case. J Oral Maxillofac Pathol 18:77–80. https://doi.org/10.4103/0973-029x.131916
Rawal YB, Anderson KM, Dodson TB (2016) Pseudomyogenic hemangioendothelioma: a vascular tumor previously Undescribed in the oral cavity. Head Neck Pathol. https://doi.org/10.1007/s12105-016-0770-1
Safadi RA, Hellstein JW, Diab MM et al (2010) Nerve sheath myxoma (Neurothekeoma) of the gingiva, a case report and review of the literature. Head Neck Pathol 4(01):242–245. https://doi.org/10.1007/s12105-010-0183-5
Sahni P, Singhvi A, Nayak MT et al (2015) Gingival rhabdomyosarcoma in an adult: a unique entity. Turk Patoloji Derg 31:153–157. https://doi.org/10.5146/tjpath.2013.01194
Savage NW, Daly CG (2010) Gingival enlargements and localized gingival overgrowths. Aust Dent J 55:55–60. https://doi.org/10.1111/j.1834-7819.2010.01199.x
Schwenzer N, Ehrenfeld M (Hrsg) (2010) Mund-Kiefer-Gesichtschirurgie. 4. Aufl. Thieme, Stuttgart
Shafer WG, Hine MK, Levy BM (1963) A textbook of oral pathology. 2nd ed. W. B. Saunders, Philadelphia
Smith MH, Reith JD, Cohen DM et al (2017) An update on myofibromas and myofibromatosis affecting the oral regions with report of 24 new cases. Oral Surg Oral Med Oral Pathol Oral Radiol 124:62–75. https://doi.org/10.1016/j.oooo.2017.03.051
Truschnegg A, Acham S, Kiefer BA et al (2016) Epulis: a study of 92 cases with special emphasis on histopathological diagnosis and associated clinical data. Clin Oral Investig 20:1757–1764. https://doi.org/10.1007/s00784-015-1665-3
Vijayalakshmi D, Fathima S, Ramakrishnan K et al (2012) Malignant fibrous histiocytoma of the gingiva. BMJ Case Rep. https://doi.org/10.1136/bcr-2012-007400
Vilos GA, Rapidis AD, Lagogiannis GD et al (2005) Leiomyosarcomas of the oral tissues: clinicopathologic analysis of 50 cases. J Oral Maxillofac Surg 63:1461–1477. https://doi.org/10.1016/j.joms.2005.06.018
Viswanathan S, Rahman K, Pallavi S et al (2010) Sarcomatoid (spindle cell) carcinoma of the head and neck mucosal region: a clinicopathologic review of 103 cases from a tertiary referral cancer centre. Head Neck Pathol 4(01):265–275. https://doi.org/10.1007/s12105-010-0204-4
Wang H‑W, Qin X‑J, Yang W‑J et al (2015) Alveolar soft part sarcoma of the oral and maxillofacial region: clinical analysis in a series of 18 patients. Oral Surg Oral Med Oral Pathol Oral Radiol 119:396–401. https://doi.org/10.1016/j.oooo.2014.12.013
Wenig BM, Childers ELB, Richardson MS et al (Hrsg) (2017) Non-neoplastic diseases of the head and neck. American Registry of Pathology, Washington, D.C.
Yuan K, Lin MT (2004) The roles of vascular endothelial growth factor and angiopoietin-2 in the regression of pregnancy pyogenic granuloma. Oral Dis 10:179–185. https://doi.org/10.1046/j.1601-0825.2003.00997.x
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D. Baumhoer, Basel
U. D. A. Müller-Richter, Würzburg
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Jundt, G. Epuliden und ihre Differenzialdiagnosen. MKG-Chirurg 11, 12–20 (2018). https://doi.org/10.1007/s12285-017-0130-5
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DOI: https://doi.org/10.1007/s12285-017-0130-5
Schlüsselwörter
- Teleangiektatisches Granulom der Gingiva
- Peripheres Riesenzellgranulom
- Fokale Gingivahyperplasie
- Peripheres ossifizierendes Fibrom
- Histologie