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C677T and A1298C methylenetetrahydrofolate reductase polymorphisms and breast cancer susceptibility among Latinos: a meta-analysis

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Abstract

Background

Previous meta-analyses have shown an ethnic dependency of the C677T and the A1298C methylenetetrahydrofolate reductase (MTHFR) polymorphisms, with no focus on the Latino population. For Latinos, many studies have examined these polymorphisms and breast cancer susceptibility, yielding no concise result. Therefore, we undertook this meta-analysis to determine the effect these polymorphisms have on breast cancer risk for Latinos.

Methods

PubMed, EBSCO, LILACS, Scopus, and Latin American-specific databases were searched for studies exploring the association between the MTHFR polymorphisms and breast cancer susceptibility in Latinos until January 2019. Genotype distributions were extracted and, depending on the level heterogeneity determined by the ψ2-based Q test and the I2 test, fixed-effects or random-effects models were used to calculate pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) for the heterozygous, homozygous, dominant, recessive, and allelic genetic models. No publication bias was detected by the Begg–Mazumdar’s test and Egger’s test.

Results

Of the 280 retrieved publications, 9 studies were included: 9 for the C677T polymorphism and 5 for the A1298C polymorphism. For the C677T polymorphism, there was an elevated risk for the homozygous (OR 1.42, 95% CI 1.05–1.92), the dominant (OR 1.16, 95% CI 1.02–1.31), the recessive (OR 1.33, 95% CI 1.01–1.75), and the allelic model (OR 1.17, 95% CI 1.03–1.33, p < 0.01). No association between the A1298C polymorphism and the risk to develop breast cancer was determined.

Conclusion

The results indicated that, for Latinos, the C677T polymorphism is associated with a significant risk for developing breast cancer, whereas the A1289C polymorphism does not.

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Acknowledgements

The authors would like to express their gratitude to Mtro. Ricardo Villegas Tovar, Coordinator of Scientific Production and International Visibility, BUAP.

Funding

This study was supported by grants from Programa para el Desarrollo Profesional Docente (to CA-160 FACMED) and Vicerrectorıa de Investigacion, Benemerita Universidad Autonoma de Puebla, Mexico (to TORE-SAL18-G, PEFR-SAL18-G, and GOMM-SAL18-I).

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Author notes

  1. Perla Meneses-Sanchez and Samantha C. Garcia-Hernandez contributed equally for the first authorship.

Authors and Affiliations

  1. Departamento de Genética, Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, 13 Sur 2901 Col. Volcanes, C.P. 72420, Puebla, Pue, Mexico

    Perla Meneses-Sanchez, Samantha C. Garcia-Hernandez, Alejandra Del Angel Soto & M. Elba Gonzalez-Mejia

  2. Laboratorio de Investigación en Fisiopatología de Enfermedades Crónicas, Centro de Investigación Biomédica de Oriente, IMSS, Km 4.5 Carretera Federal Atlixco-Metepec, C.P. 42730, Atlixco, Puebla, Mexico

    Leonardo M. Porchia & Ricardo Pérez-Fuentes

  3. Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, 13 Sur 2901 Col. Volcanes, C.P. 72420, Puebla, Pue, Mexico

    Ricardo Pérez-Fuentes & Enrique Torres-Rasgado

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  1. Perla Meneses-Sanchez
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Correspondence to M. Elba Gonzalez-Mejia.

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Meneses-Sanchez, P., Garcia-Hernandez, S.C., Porchia, L.M. et al. C677T and A1298C methylenetetrahydrofolate reductase polymorphisms and breast cancer susceptibility among Latinos: a meta-analysis. Breast Cancer 26, 602–611 (2019). https://doi.org/10.1007/s12282-019-00961-8

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