Skip to main content

Advertisement

Log in

Zygomycete Fungi Infection in Colombia: Literature Review

  • Clinical Mycology Lab Issues (S Córdoba, Section Editor)
  • Published:
Current Fungal Infection Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

This review summarizes the reports of Zygomycete fungi infection in Colombia, as well as include the geographical distribution, species identification, and treatment of those clinical cases.

Recent Findings

Zygomycosis is not a new disease. However, the use of molecular tools has allowed the identification of some recently described species as their causal agents.

Summary

In Colombia, the prevalence of zygomycosis is unclear because reporting is not mandatory and because in many cases the etiological agent was not identified. It is important to establish the mandatory reporting of cases, to know the circulating fungal species, the treatment used, and the outcome of the patients. Regarding the treatment, amphotericin B remains as the best alternative. To our knowledge, this is the first compilation of the published cases of zygomicosis in the country.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. •• Spatafora JW, Chang Y, Benny GL, Lazarus K, Smith ME, Berbee ML, et al. A phylum-level phylogenetic classification of zygomycete fungi based on genome-scale data. Mycologia. 2016;108(5):1028–46 They proposed significant changes in the phylogenetic classification of Zygomycete fungi.

    Article  CAS  Google Scholar 

  2. Ribes JA, Vanover-Sams CL, Baker DJ. Zygomycetes in human disease. Clin Microbiol Rev. 2000;13(2):236–301.

    Article  CAS  Google Scholar 

  3. Mendoza L, Vilela R, Voelz K, Ibrahim AS, Voigt K, Lee SC. 243 Human fungal pathogens of Mucorales and Entomophthorales. 244 Cold Spring Harb Perspect Med 2015;5: 4.https://doi.org/10.1101/cshperspect.a019562

  4. Roden MM, Zaoutis TE, Buchanan WL, Knudsen TA, Sarkisova TA, Schaufele RL, et al. Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin Infect Dis. 2005;41(5):634–53.

  5. Prabhu RM, Patel R. Mucormycosis and entomophthoramycosis: a review of the clinical manifestations, diagnosis and treatment. Clin Microbiol Infect. 2004;10(Suppl 1):31–47.

    Article  Google Scholar 

  6. Richardson M. The ecology of the Zygomycetes and its impact on environmental exposure. Clin Microbiol Infect. 2009;15:2–9.

    Article  Google Scholar 

  7. Muszewska A, Pawłowska J, Krzyściak P. Biology, systematics, and clinical manifestations of Zygomycota infections. Eur J Clin Microbiol Infect Dis. 2014;33(8):1273–87.

    Article  CAS  Google Scholar 

  8. Ajello L, Dean DF, Irwin RS. The zygomycete Saksenaea vasiformis as a pathogen of humans with a critical review of the etiology of zygomycosis. Mycologia. 1976;68:52–62.

    Article  CAS  Google Scholar 

  9. Kwon-Chung KJ. Taxonomy of fungi causing mucormycosis and entomophthoramycosis ( zygomycosis) and nomenclature of the disease: molecular mycologic perspectives. Clin Infect Dis. 2012;54(Suppl 1):S8–15.

    Article  Google Scholar 

  10. Departamento Administrativo Nacional de Estadística, DANE. http://www.dane.gov.co/reloj/ «Generalidades del País». Banco de la República - Colombia. Consultado el 11 de mayo de 2018 http://www.banrepcultural.org/blaavirtual/economia/colombia/eco1.htm.

  11. Herrera-López MA, Lora-Suarez FM, Loango-Chamorro N, Herrera López M. Identificación de microorganismos aislados apartir de lodos residuales de una planta de tratamiento de un sector curtidor del quindío. Rev Asoc Col Cienc( Col). 2017;29:103–18.

    Google Scholar 

  12. Cardozo Becerra RY, Araque Muñoz LG. Caracterización de bioaerosoles en tres edificaciones administrativas de Bogotá characterization of bioaerosols in administrative buildings in Bogotá. Rev Cienc Desarro. 2015;6(1):41–54.

    Article  Google Scholar 

  13. Trujillo H. Monografía sobre la mucormicosis en pediatría. Anot Pediatr. 1961;4:296.

    Google Scholar 

  14. Lopez H, Hurtado H, Correa C. Las Micosis Profundas en el 278 Hospital de San Juan de Dios. Trabajo Presentado en el III Congreso 279 Nacional Patolología Febrero 1964

  15. Leon L, Correas A. Presentación de casos clínicos: zigomicosis subcutanea cronica complicada con noma de Madagascar. Act Med Colomb. 1990;15(5):164–9.

    Google Scholar 

  16. Botero S, Arango M, Vélez I, Vélez G. El caso de infecciosas: Zigomicosis rino-facial. Medicina UPB 1994; 13 (2) 131–7. https://revistas.upb.edu.co/index.php/Medicina/article/view/1826

  17. Ochoa L, Duque C, Velez A. Report of two cases. J Laryngol Otol. 1996;110:1154–6.

    Article  CAS  Google Scholar 

  18. Jaramillo C, Tobon A, Franco L, Arango M, Restrepo A. Rinoentomoftoramicosis. 1996;15:135–42.

    Google Scholar 

  19. Murillo V, Robledo M. Entomoftoramicosis sistémica con compromiso mediastinal, pulmonar y pancreático. Informe de caso y revisión de tema. Medicina UPB. 1996;1451–8.

  20. Pérez JA, Correa Á, Fuentes J, Meléndez E. Conidiobolomicosis: hallazgos histopatológicos. Biomedica. 2004;24:350–5.

    Article  Google Scholar 

  21. Tobón AM, Arango M, Fernández D, Restrepo A. Mucormycosis (zygomycosis) in a heart-kidney transplant recipient: recovery after posaconazole therapy. Clin Infect Dis. 2003;36(11):1488–91.

    Article  Google Scholar 

  22. Ruiz C, Arango M, Correa A, López L, Restrepo A. Fascitis necrosante por Apophysomyces elegans, moho de la familia mucoraceae, en paciente inmunocompetente. Biomedica. 2004;24:239–51.

    Article  Google Scholar 

  23. Gómez CH, Rivas P, García MH. Mucormicosis fatal en un paciente con linfoma no hodgkin linfoblástico en quimioterapia paliativa fatal Mucormicosis in a patient with non lymphoblastic non Hodgkin lymphoma treated with palliative chemotherapy. Rev Colomb Cancerol. 2005;9(4):227–30.

    Google Scholar 

  24. Botero JC, Moreno LF, Caparroso LC. Mucormicosis rinocerebral en paciente con cefalea y diabetes mellitus Rhinocerebral mucormycosis in diabetic patient with headache. Rev Colomb Infectol. 2008;12(1):298–303.

    Google Scholar 

  25. Peña C. Micosis del sistema nervioso central, estudio clinico-patologico de diez casos. Rev Fac Med. 1966;34:107–22.

    Google Scholar 

  26. Herrera DA, Dublin AB, Ormsby EL, Aminpour S, Howell LP. Imaging findings of rhinocerebral mucormycosis. Skull Base. 2009;19(2):117–26.

    Article  Google Scholar 

  27. Ruiz C, Pareja M. Mucormicosis rinocerebral: una mirada a la literatura, a propósito de un caso. Acta Colomb Cuid Intensivo. 2009; 9(1):30-5. http://www.anestesianet.com/actacci/ActaColCuidadoCriticoMar09.pdf%23page=19

  28. García C, García E, Gómez C, Andrés Castillo S. Mucormicosis gastrointestinal en paciente diabético; reporte de un caso y revisión de la literatura. Infection. 2012;16(Supl 3):108–13.

    Article  Google Scholar 

  29. Nieto-Ríos JF, Moreno-Coral LF, Zapata-Cárdenas A, Ocampo-Kohn C, Aristizabal-Alzate A, Serna-Higuita LM, et al. Tratamiento exitoso de mucormicosis rino-órbito-cerebral en un paciente trasplantado renal. Nefrologia. 2014;34(1):120–4.

  30. Peralta D, Albán J, Rivera C. Mucormicosis pulmonar en paciente inmunocompetente y sin factores predisponentes tradicionalmente descritos. Rev Colomb Salud Libr. 2015;10(1):78–9.

    Google Scholar 

  31. Quiroz N, Janeth V Necrosis facial rapidamente progresiva 2015. p. 1.

  32. Moncada DC, Montes M, Molina V, Velásquez JB, Gómez CI. Infección orofacial por Conidiobolus coronatus. Biomedica. 2016;36:15–22.

    Article  Google Scholar 

  33. • Rey D, Bernal L, Linares M, Parra CM, Garzón J, Valderrama S, Cañas A. Invasive fungal infection in immunosuppressed patients treated in a tertiary hospital (Infección fúngica invasiva en pacientes inmunosuprimidos atendidos en un hospital de tercer nivel). Rev Colomb Neumol 2016;28 (1) 10-6. http://revistas.asoneumocito.org/index.php/rcneumologia/article/view/159 Perhaps the largest study conducted in the country that included 80 immunosuppressed patients suspected of invasive fungal infections, in which the demographic and clinical features of the patients treated with antifungals.

  34. • Rodríguez JY, Rodríguez GJ, Morales-López SE, Cantillo CE, Le Pape P, Álvarez-Moreno CA. Saksenaea erythrospora infection after medical tourism for esthetic breast augmentation surgery. Int J Infect Dis. 2016;49:1–4 Report the first case of infection by Sakseanea erythrospora in Colombia, and the third case in the world. In addition, the description of the first case of infection by Sakseanea erythrospora that has been associated with medical tourism.

    Article  Google Scholar 

  35. Bravo J, Agudelo M, Cortes A, Matta L. Mucormicosis rinoorbitocerebral de origen dental. Biomedica 2018;38:27-31. https://doi.org/10.7705/biomedica.v38i0.3383

  36. Restrepo A, Greer D, D R RL, Bravo C. Subcutaneous phycomycosis: report of the first case observed in Colombia, South America. Am J Trop Med Hyg. 1967;16:34.

    Article  CAS  Google Scholar 

  37. Rodríguez JY, Morales-López SE, Rodríguez GJ, Álvarez-Moreno CA, Ocampo W, Cepeda ML, et al. Necrotizing fasciitis caused by Apophysomyces variabilis in an immunocompetent patient. Med Mycol Case Rep. 2017;20(December 2017):4–6.

    PubMed  PubMed Central  Google Scholar 

  38. Garcia V, Murgueitio C, Varon C, Balcazar C, Casanova M, Ocampo J. Mucormicosis Rinocerebral: una enfermedad para considerar. X Congr Latinoam Micol. 2017;42:105.

    Google Scholar 

  39. Jaramillo L, Castro T, Maya L. Mucormicosis asociada a cetoacidosis diabética Actual. Pediatria (Santiago). 1999;9(1):12–6.

    Google Scholar 

  40. Duque C, González Noreña H, Lopera CF. Otorhinolaryngological manifestations of mucormycosis. Study of 6 cases. Acta Otorrinolaringol Esp. 1996;4:291–5.

    Google Scholar 

  41. Pedraza MA. Mycotic infections at autopsy. Am J Clin Pathol. 1969;51(4):470–6.

    Article  CAS  Google Scholar 

  42. Bedoya V, Penagos L. Entomoftoromicosis nasofacial (Rinoficomicosis). Ant Med. 1981;30:53–9.

    Google Scholar 

  43. Restrepo G, Sanín A, Orrego A, Betancur J, Mesa A, Velez H, et al. Mucormicosis: presentación de cuatro casos con formas clínicas. Ant Med. 1983;32(4):191–7.

    Google Scholar 

  44. Patiño JF, Mora R, Guzmán MA, Rodríguez-Franco E. Mucormycosis: a fatal case by Saksenaea vasiformis. World J Surg. 1984;8(3):419–22.

    Article  Google Scholar 

  45. Supelano G, Cantini J, Robledo L, Guzman M, Garcia C. Presentacion De Casos Clinicos. Acta Med Col. 1987;12:304–12.

    Google Scholar 

  46. Castro D. Mucormicosis Postraumatica en Ocho Pacientes Sobrevivientes de la Catastrofe Volcanica de Armero ( Colombia). 1988. 48 p.

  47. Paultauf A. Mycosis mucorina. Arch Path Anat. 1885;102:543–64.

    Article  Google Scholar 

  48. •• Alvarez C, Cortes J, Denning D. Burden of fungal infections in Colombia. J. Fungi. 2018;4:41. https://doi.org/10.3390/jof4020041 A complete and recent panorama of the burden of the most important fungal infections in Colombia.

    Article  Google Scholar 

  49. Peña C, Dorado J. Mucormicosis (ficomicosis) en Colombia: Presentación de dos casos. Rev. Fac. Med (Bogotá). 1965; 33: 205.

  50. Liu M, Lin L, Gebremariam T, Luo G, Skory CD, French SW, et al. Fob1 and Fob2 proteins are virulence determinants of Rhizopus oryzae via facilitating iron uptake from Ferrioxamine. PLoS Pathog. 2015;11(5):1–33.

    Article  Google Scholar 

  51. Ibrahim AS, Spellberg B, Walsh TJ, Kontoyiannis DP. Pathogenesis of mucormycosis. Clin Infect Dis. 2012;54(SUPPL. 1):S16–22.

    Article  CAS  Google Scholar 

  52. Álvarez F, Fernández-Ruiz M, Aguado JM. Iron and invasive fungal infection. Rev Iberoam Micol (Internet). 2013;30(4):217–25. Disponible en: https://doi.org/10.1016/j.riam.2013.04.002

  53. Mucormycosis Caused by Unusual Mucormycetes, Non-Rhizopus, -Mucor, and Lichtheimia Species. Clin. Microbiol. Rev. Vol. 24, Apr. 2011, p. 411–445. https://doi.org/10.1128/CMR.00056-10.

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Soraya Morales-López.

Ethics declarations

Conflict of Interest

The authors declare that they have no competing interests.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

This article is part of the Topical Collection on Clinical Mycology Lab Issues

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Morales-López, S., Ceballos-Garzón, A. & Parra-Giraldo, C.M. Zygomycete Fungi Infection in Colombia: Literature Review. Curr Fungal Infect Rep 12, 149–154 (2018). https://doi.org/10.1007/s12281-018-0326-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12281-018-0326-9

Keywords

Navigation