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Tinea Capitis: Current Review of the Literature

  • Fungal Infections of Skin and Subcutaneous Tissue (A Bonifaz, Section Editor)
  • Published:
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Abstract

Purpose of Review

This review summarizes the fungal literature currently available for tinea capitis (TC), as well as providing data for clinical utility.

Recent Findings

Available studies in TC are scarce; however, they provide important information about efficacy and outcome in clinical practice.

Summary

Treatment of TC is effective; however, it requires a minimum of 1 month. Systemic treatment is often required to favor enhance drug penetration into the deep part of the hair follicle. The newest oral antifungal has higher efficacy rates than conventional therapy, as well as much shorter duration of treatment but at higher costs. We perform a review of the literature including treatment schemes.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major Importance

  1. Bennassar A, Grimalt R. Management of tinea capitis in childhood. Clin Cosmet Investig Dermatol. 2010;3:89–98.

    PubMed  PubMed Central  CAS  Google Scholar 

  2. • Rebollo N, López-Barcenas AP, Arenas R. Tinea capitis. Actas Dermosifiliogr. 2008;99(2):91–100. This paper is an overview of the disease.

    Article  PubMed  CAS  Google Scholar 

  3. Hay RJ, Robles W, Midgley G, Moore MK. European Confederation of Medical Mycology Working Party on Tinea Capitis. Tinea capitis in Europe: new perspective on an old problem. J Eur Acad Dermatol Venereol. 2001;15(3):229–33.

    Article  PubMed  CAS  Google Scholar 

  4. • Kallel A, Hdider A, Fakhfakh N, Belhadj S, Belhadj-Salah N, Bada N, et al. Tinea capitis: main mycosis child. Epidemiological study on 10 years. J Mycol Med. 2017;27(3):345–50. This paper showed the most common clinical manifestations of tinea capitis in children.

    Article  PubMed  CAS  Google Scholar 

  5. Ziegler W, Lempert S, Goebeler M, Kolb-Mäurer A. Tinea capitis: temporal shift in pathogens and epidemiology. J Dtsch Dermatol Ges. 2016;14(8):818–25. (Abstract)

    PubMed  Google Scholar 

  6. Kieliger S, Glatz M, Cozzio A, Bosshard PP. Tinea capitis and tinea faciei in the Zurich area - an 8-year survey of trends in the epidemiology and treatment patterns. J Eur Acad Dermatol Venereol. 2015;29(8):1524–9.

    Article  PubMed  CAS  Google Scholar 

  7. Sei Y. 2011 epidemiological survey of dermatomycoses in Japan. Med Mycol J. 2015;56(4):J129–35.

    Article  PubMed  CAS  Google Scholar 

  8. • Brito-Santos F, Figueiredo-Carvalho MHG, Coelho RA, Sales A, Almeida-Paes R. Tinea capitis by Microsporum audouinii: case reports and review of published global literature 2000‑2016. Mycopathologia. 2017;182(11–12):1053–60. An important review of the disease mainly on therapeutic options

    Article  PubMed  CAS  Google Scholar 

  9. Niczyporuk W, Krajewska-Kułak E, Łukaszuk C. Tinea capitis favosa in Poland. Mycoses. 2004;47(5–6):257–60.

    Article  PubMed  CAS  Google Scholar 

  10. Khosravi AR, Shokri H, Vahedi G. Factors in etiology and predisposition of adult tinea capitis and review of published literature. Mycopathologia. 2016;181(5–6):371–8.

    Article  PubMed  Google Scholar 

  11. •• Hay RJ. Tinea capitis: current status. Mycopathologia. 2017;182(1–2):87–93. This paper gives important strategies for treating tinea capitis.

    Article  PubMed  CAS  Google Scholar 

  12. Martínez-Suárez H, Guevara-Cabrera N, Mena C, Valencia A, Araiza J, Bonifaz A. Tiña de la cabeza. Reporte de 122 casos. Derma CMQ. 2007;5(1):9–14.

    Google Scholar 

  13. Bonifaz A, Carrasco-Gerard E, Palacios-López C, Araiza J. Tratamiento de la cabeza con dosis intermitentes (semanales) de fluconazol. Derma Cosmet Med Quir. 2003;1:11–9.

    Google Scholar 

  14. Gupta AK, Summerbell RC. Tinea capitis. Med Mycol. 2000;38(4):255–87.

    Article  PubMed  CAS  Google Scholar 

  15. Ilkit M, Demirhindi H. Asymptomatic dermatophyte scalp carriage: laboratory diagnosis, epidemiology and management. Mycopathologia. 2008;165(2):61–71.

    Article  PubMed  Google Scholar 

  16. Zurita J, Hay RJ. Adherence of dermatophyte microconidia and arthroconidia to human keratinocytes in vitro. J Investig Dermatol. 1987;89(5):529–34.

    Article  PubMed  CAS  Google Scholar 

  17. Sriranganadane D, Waridel P, Salamin K, Feuermann M, Mignon B, Staib P, et al. Identification of novel secreted proteases during extracellular proteolysis by dermatophytes at acidic pH. Proteomics. 2011;11(22):4422–33.

    Article  PubMed  CAS  Google Scholar 

  18. Staib P, Zaugg C, Mignon B, Weber J, Grumbt M, Pradervand S, et al. Differential gene expression in the pathogenic dermatophyte Arthroderma benhamiae in vitro versus during infection. Microbiology. 2010;156(Pt3):884–95.

    Article  PubMed  CAS  Google Scholar 

  19. Niyonsaba F, Ogawa H. Protective roles of the skin against infection: implication of naturally occurring human antimicrobial agents beta-defensins, cathelicidin LL-37 and lysozyme. J Dermatol Sci. 2005;40(3):157–68.

    Article  PubMed  CAS  Google Scholar 

  20. Abdelaal NH, Rashed LA, Ibrahim SY, Abd El Halim MH, Ghoneim N, Saleh NA, et al. Cathelicidin (LL-37) level in the scalp hair of patients with tinea capitis. Med Mycol. 2017;55(7):733–6.

    PubMed  Google Scholar 

  21. Mao L, Zhang L, Li H, Chen W, Wang H, Wu S, et al. Pathogenic fungus Microsporum canis activates the NLRP3 inflammasome. Infect Immun. 2014;82(2):882–92.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  22. Wagner DK, Sohnle PG. Cutaneous defenses against dermatophytes and yeasts. Clin Microbiol Rev. 1995;8(3):317–35.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  23. Calderon RA, Hay RJ. Fungicidal activity of human neutrophils and monocytes on dermatophyte fungi, Trichophyton quinckeanum and Trichophyton rubrum. Immunology. 1987;61(3):289–95.

    PubMed  PubMed Central  CAS  Google Scholar 

  24. Sakuragi Y, Sawada Y, Hara Y, Ohmori S, Omoto D, Haruyama S, et al. Increased circulating Th17 cell in a patient with tinea capitis caused by Microsporum canis. Allergol Int. 2016;65(2):215–6.

    Article  PubMed  CAS  Google Scholar 

  25. Gorgievska-Sukarovska B, Skerlev M, Žele-Starčević L, Husar K, Halasz M. Kerion celsi due to Microsporum canis with a dermatophytid reaction. Acta Dermatovenerol Croat. 2017;25(2):151–4.

    PubMed  Google Scholar 

  26. Brissos J, Gouveia C, Neves C, Varandas L. Remember kerion celsi. BMJ Case Rep. 2013;2013

  27. de Hoog GS, Dukik K, Monod M, Packeu A, Stubbe D, Hendrickx M, et al. Toward a novel multilocus phylogenetic taxonomy for the dermatophytes. Mycopathologia. 2017;182(1–2):5–31.

    Article  PubMed  Google Scholar 

  28. Farooqi M, Tabassum S, Rizvi DA, Rahman A, Rehanuddin, Awan S, et al. Clinical types of tinea capitis and species identification in children: an experience from tertiary care centres of Karachi, Pakistan. J Pak Med Assoc. 2014;64(3):304–8.

    PubMed  Google Scholar 

  29. Kefalidou S, Odia S, Gruseck E, Schmidt T, Ring J, Abeck D. Wood’s light in Microsporum canis positive patients. Mycoses. 1997;40(11–12):461–3.

    Article  PubMed  CAS  Google Scholar 

  30. Robert R, Pihet M. Conventional methods for the diagnosis of dermatophytosis. Mycopathologia. 2008;166(5–6):295–306.

    Article  PubMed  Google Scholar 

  31. Symoens F, Jousson O, Planard C, Fratti M, Staib P, Mignon B, et al. Molecular analysis and mating behaviour of the Trichophyton mentagrophytes species complex. Int J Med Microbiol. 2011;301(3):260–6.

    Article  PubMed  CAS  Google Scholar 

  32. Kanbe T, Suzuki Y, Kamiya A, Mochizuki T, Kawasaki M, Fujihiro M, et al. Species-identification of dermatophytes Trichophyton, Microsporum and Epidermophyton by PCR and PCR-RFLP targeting of the DNA topoisomerase II genes. J Dermatol Sci. 2003;33(1):41–54.

    Article  PubMed  CAS  Google Scholar 

  33. Brillowska-Dabrowska A, Michałek E, Saunte DM, Nielsen SS, Arendrup MC. PCR test for Microsporum canis identification. Med Mycol. 2013;51(6):576–9.

    Article  PubMed  CAS  Google Scholar 

  34. Verrier J, Krähenbühl L, Bontems O, Fratti M, Salamin K, Monod M. Dermatophyte identification in skin and hair samples using a simple and reliable nested polymerase chain reaction assay. Br J Dermatol. 2013;168(2):295–301.

    Article  PubMed  CAS  Google Scholar 

  35. Deng S, Zhou Z, de Hoog GS, Wang X, Abliz P, Sun J, et al. Evaluation of two molecular techniques for rapid detection of the main dermatophytic agents of tinea capitis. Br J Dermatol. 2015;173(6):1494–500.

    Article  PubMed  CAS  Google Scholar 

  36. Deng S, de Hoog GS, Verweij PE, Zoll J, Ilkit M, Morsali F, et al. In vitro antifungal susceptibility of Trichophyton violaceum isolated from tinea capitis patients. J Antimicrob Chemother. 2015;70(4):1072–5.

    PubMed  CAS  Google Scholar 

  37. Brasileiro A, Campos S, Cabete J, Galhardas C, Lencastre A, Serrão V. Trichoscopy as an additional tool for the differential diagnosis of tinea capitis: a prospective clinical study. Br J Dermatol. 2016;175(1):208–9.

    Article  PubMed  CAS  Google Scholar 

  38. Elghblawi E. Tinea capitis in children and trichoscopic criteria. Int J Trichology. 2017;9(2):47–9.

    PubMed  PubMed Central  Google Scholar 

  39. Lu M, Ran Y, Dai Y, Lei S, Zhang C, Zhuang K, et al. An ultrastructural study on corkscrew hairs and cigarette-ash-shaped hairs observed by dermoscopy of tinea capitis. Scanning. 2016;38(2):128–32.

    Article  PubMed  Google Scholar 

  40. Schechtman RC, Silva ND, Quaresma MV, Bernardes Filho F, Buçard AM, Sodré CT. Dermatoscopic findings as a complementary tool in the differential diagnosis of the etiological agent of tinea capitis. An Bras Dermatol. 2015;90(3 Suppl 1):13–5.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Campos S, Brasileiro A, Galhardas C, Apetato M, Cabete J, Serrão V, et al. Follow-up of tinea capitis with trichoscopy: a prospective clinical study. J Eur Acad Dermatol Venereol. 2017;31(11):e478–80.

    Article  PubMed  CAS  Google Scholar 

  42. Arrazola-Guerrero J, Isa-Isa R, Torres-Guerrero E, Arenas R. Tinea capitis. Dermoscopic findings in 37 patients. Rev Iberoam Micol. 2015;32(4):242–6.

    Article  PubMed  Google Scholar 

  43. Velho GD, Selores M, Amorim I, Lopes V. Guess what! Tinea capitis by Trichophyton schöenleinii. Eur J Dermatol. 2001;11(5):481–2.

    PubMed  CAS  Google Scholar 

  44. Fuller LC, Barton RC, Mohd Mustapa MF, Proudfoot LE, Punjabi SP, Higgins EM. British Association of Dermatologists’ guidelines for the management of tinea capitis 2014. Br J Dermatol. 2014;171(3):454–63.

    Article  PubMed  CAS  Google Scholar 

  45. Chen X, Jiang X, Yang M, González U, Lin X, Hua X, et al. Systemic antifungal therapy for tinea capitis in children. Cochrane Database Syst Rev. 2016;5:CD004685.

    Google Scholar 

  46. •• Chen X, Jiang X, Yang M, Bennett C, González U, Lin X, et al. Systemic antifungal therapy for tinea capitis in children: an abridged Cochrane review. J Am Acad Dermatol. 2017;76(2):368–74. An important paper that summarizes the clinical trials available for tinea capitis

    Article  PubMed  Google Scholar 

  47. Tey HL, Tan AS, Chan YC. Meta-analysis of randomized, controlled trials comparing griseofulvin and terbinafine in the treatment of tinea capitis. J Am Acad Dermatol. 2011;64(4):663–70.

    Article  PubMed  CAS  Google Scholar 

  48. Shemer A, Grunwald MH, Gupta AK, Lyakhovitsky A, Daniel CR 3rd, Amichai B. Griseofulvin and fluconazole reduce transmission of tinea capitis in schoolchildren. Pediatr Dermatol. 2015;32(5):696–700.

    Article  PubMed  Google Scholar 

  49. Danielli LJ, Lopes W, Vainstein MH, Fuentefria AM, Apel MA. Biofilm formation by Microsporum canis. Clin Microbiol Infect. 2017;23(12):941–2.

    Article  PubMed  CAS  Google Scholar 

  50. Shemer A, Plotnik IB, Davidovici B, Grunwald MH, Magun R, Amichai B. Treatment of tinea capitis - griseofulvin versus fluconazole - a comparative study. J Dtsch Dermatol Ges. 2013;11(8):737–41–2. (Abstract)

    Google Scholar 

  51. Kakourou T, Uksal U, European Society for Pediatric Dermatology. Guidelines for the management of tinea capitis in children. Pediatr Dermatol. 2010;27(3):226–8.

    Article  PubMed  Google Scholar 

  52. Papaiordanou F, da Silveira BR, Abulafia LA. Hypersensitivity reaction to Sporothrix schenckii: erythema nodosum associated with sporotrichosis. Rev Soc Bras Med Trop. 2015;48(4):504.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Dermatology Department, Hospital General de México, Dr. Balmis 148, Col. Doctores, Deleg. Cuauhtémoc, 06726, Mexico City, DF, Mexico

    Andrés Tirado-Sánchez & Alexandro Bonifaz

  2. Internal Medicine Department, Instituto Mexicano del Seguro Social, Hospital General de Zona #29, Mexico City, Mexico

    Andrés Tirado-Sánchez

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  1. Andrés Tirado-Sánchez
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  2. Alexandro Bonifaz
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Correspondence to Andrés Tirado-Sánchez.

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This article is part of the Topical Collection on Fungal Infections of Skin and Subcutaneous Tissue

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Tirado-Sánchez, A., Bonifaz, A. Tinea Capitis: Current Review of the Literature. Curr Fungal Infect Rep 12, 120–126 (2018). https://doi.org/10.1007/s12281-018-0320-2

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  • DOI: https://doi.org/10.1007/s12281-018-0320-2

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