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Interdependence between iron acquisition and biofilm formation in Pseudomonas aeruginosa

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Abstract

Bacterial biofilms remain a persistent threat to human healthcare due to their role in the development of antimicrobial resistance. To combat multi-drug resistant pathogens, it is crucial to enhance our understanding of not only the regulation of biofilm formation, but also its contribution to bacterial virulence. Iron acquisition lies at the crux of these two subjects. In this review, we discuss the role of iron acquisition in biofilm formation and how hosts impede this mechanism to defend against pathogens. We also discuss recent findings that suggest that biofilm formation can also have the reciprocal effect, influencing siderophore production and iron sequestration.

Keywords

iron acquisition biofilm nutritional immunity siderophore exopolysaccharides Pseudomonas aeruginosa 

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© The Microbiological Society of Korea and Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Department of BiosciencesRice UniversityHoustonUSA

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