Journal of Microbiology

, Volume 55, Issue 4, pp 231–236 | Cite as

Plasmodium falciparum apicoplast and its transcriptional regulation through calcium signaling

  • Praveen Rai
  • Drista Sharma
  • Rani Soni
  • Nazia Khatoon
  • Bhaskar Sharma
  • Tarun Kumar Bhatt


Malaria has been present since ancient time and remains a major global health problem in developing countries. Plasmodium falciparum belongs to the phylum Apicomplexan, largely contain disease-causing parasites and characterized by the presence of apicoplast. It is a very essential organelle of P. falciparum responsible for the synthesis of key molecules required for the growth of the parasite. Indispensable nature of apicoplast makes it a potential drug target. Calcium signaling is important in the establishment of malaria parasite inside the host. It has been involved in invasion and egress of merozoites during the asexual life cycle of the parasite. Calcium signaling also regulates apicoplast metabolism. Therefore, in this review, we will focus on the role of apicoplast in malaria biology and its metabolic regulation through Ca++ signaling.


malaria Plasmodium falciparum apicoplast calcium signaling transcription regulation 


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Copyright information

© The Microbiological Society of Korea and Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Praveen Rai
    • 1
  • Drista Sharma
    • 1
  • Rani Soni
    • 1
  • Nazia Khatoon
    • 1
  • Bhaskar Sharma
    • 1
  • Tarun Kumar Bhatt
    • 1
  1. 1.School of Life Science, Department of BiotechnologyCentral University of RajasthanBandarSindri, AjmerIndia

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