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Schiff-base silver nanocomplexes formation on natural biopolymer coated mesoporous silica contributed to the improved curative effect on infectious microbes

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Abstract

Infectious microbes that spread easily in healthcare facilities remain as the severe threat for the public health, especially among immunocompromised populations. Given the intricate problem of dramatic increase in resistance to common biocides, the development of safe and efficient biocide formulated agents to alleviate drug resistance is highly demanding. In this study, Schiff-base ligands were successfully formed on natural biopolymer of epsilon-poly-L-lysine (ε-PL) decorated aldehyde functionalized mesoporous silica SBA-15 (CHO-SBA-15) for the selective coordination of silver ions, which was affirmed by various physicochemical methods. Besides the identified broad-spectrum antibacterial activities, the as-prepared Schiff-base silver nanocomplex (CHO-SBA-15/ε-PL/Ag, CLA-1) exhibited an improved inhibitory effect on infectious pathogen growth typified by Escherichia coli and Staphylococcus aureus in comparison with two control silver complexes without Schiff-base conjugates, SBA-15/ε-PL/Ag and CHO-SBA-15/Ag, respectively. In addition, CLA-1 remarkably inhibited the growth of Mycobacterium tuberculosis due to the excellent antimicrobial activity of silver species. Significantly, CLA-1 kills Candida albicans cells, inhibits biofilm formation, and eliminates preformed biofilms, with no development of resistance during continuous serial passaging. The antifungal activity is connected to disruption of bacterial cell membranes and increased levels of intracellular reactive oxygen species. In mouse models of multidrug-resistant C. albicans infection, CLA-1 exhibited efficient in vivo fungicidal efficacy superior to two antifungal drugs, amphotericin B and fluconazole. Moreover, CLA-1 treatment induces negligible toxicity against normal tissues with safety. Therefore, this study reveals the pivotal role of the molecular design of Schiff-base silver nanocomplex formation on biopolymer surface-functionalized silica mesopores as a green and efficient nanoplatform to tackle infectious microbes.

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Acknowledgements

This work was supported by the National Key R&D Programs of China (No. 2018YFC0311003 to H. B.), the National Natural Science Foundation of China (No. U1703118 to J. C.), the Natural Science Foundation of Jiangsu Province (No. BK20181364 to J. C.), the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD, to J. C.), the Cooperative Project between Southeast University and Nanjing Medical University (No. 2018DN0004 to J. C.), the National Science Foundation of the Jiangsu Higher Education Institutions of China (No. 18KJA310002 to H. B., No. 19KJA310003 to J. C.), the Jiangsu Specially Appointed Professor and Jiangsu Medical Specialist Programs of China (to H. B.), and Jiangsu Province “Innovative and Entrepreneurial Team” Program.

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Author notes

  1. Ling Cai, Yanqiang Huang, Yuanyuan Duan, and Qiao Liu contribute equally to this work.

Authors and Affiliations

  1. Center for Global Health, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, China

    Ling Cai, Qiao Liu, Qilan Xu, Jianming Wang, Ping Zhu & Jin Chen

  2. Department of Pathogen Biology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, 211166, China

    Yanqiang Huang, Jia Jia, Qian Tong, Peipei Luo, Qian Wu, Xudong Hang, Yanmei Yang, Boshen Zhou, Liping Zeng & Hongkai Bi

  3. Research Center for the Prevention and Treatment of Drug Resistant Microbial Infecting, Youjiang Medical University for Nationalities, Baise, 533000, China

    Yanqiang Huang

  4. The Laboratory Center for Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China

    Yuanyuan Duan

  5. Key Laboratory of Mesoscopic Chemistry of MOE and Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China

    Yujie Wen & Luming Peng

  6. School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China

    Huijun Jiang

  7. Department of Gastroenterology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, China

    Hongkai Bi

  8. Key Laboratory of Antibody Technique of National Health Commission, Nanjing Medical University, Nanjing, 211166, China

    Jin Chen

Authors
  1. Ling Cai
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  2. Yanqiang Huang
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  3. Yuanyuan Duan
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  4. Qiao Liu
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  5. Qilan Xu
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  6. Jia Jia
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  7. Jianming Wang
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  8. Qian Tong
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  9. Peipei Luo
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  10. Yujie Wen
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  11. Luming Peng
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  12. Qian Wu
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  13. Xudong Hang
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  14. Huijun Jiang
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  15. Ping Zhu
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  16. Yanmei Yang
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  17. Boshen Zhou
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  18. Liping Zeng
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  19. Hongkai Bi
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  20. Jin Chen
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Corresponding authors

Correspondence to Hongkai Bi or Jin Chen.

Electronic supplementary material

12274_2020_3279_MOESM1_ESM.pdf

Schiff-base silver nanocomplexes formation on natural biopolymer coated mesoporous silica contributed to the improved curative effect on infectious microbes

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Cai, L., Huang, Y., Duan, Y. et al. Schiff-base silver nanocomplexes formation on natural biopolymer coated mesoporous silica contributed to the improved curative effect on infectious microbes. Nano Res. 14, 2735–2748 (2021). https://doi.org/10.1007/s12274-020-3279-6

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  • DOI: https://doi.org/10.1007/s12274-020-3279-6

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